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BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss

We aimed to ascertain the interaction and effects of combined reactivations of BK virus and cytomegalovirus on kidney graft function. All consecutive kidney transplant recipients (KTR) between 2003 and 2016 were included. Of 1976 patients who received a kidney transplant, 23 (1.2%) presented BKV-ass...

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Autores principales: Herrera, Sabina, Bernal-Maurandi, Javier, Cofan, Frederic, Ventura, Pedro, Marcos, Maria Angeles, Linares, Laura, Cuesta, Genoveva, Diekmann, Fritz, Moreno, Asunción, Bodro, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432040/
https://www.ncbi.nlm.nih.gov/pubmed/34501226
http://dx.doi.org/10.3390/jcm10173779
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author Herrera, Sabina
Bernal-Maurandi, Javier
Cofan, Frederic
Ventura, Pedro
Marcos, Maria Angeles
Linares, Laura
Cuesta, Genoveva
Diekmann, Fritz
Moreno, Asunción
Bodro, Marta
author_facet Herrera, Sabina
Bernal-Maurandi, Javier
Cofan, Frederic
Ventura, Pedro
Marcos, Maria Angeles
Linares, Laura
Cuesta, Genoveva
Diekmann, Fritz
Moreno, Asunción
Bodro, Marta
author_sort Herrera, Sabina
collection PubMed
description We aimed to ascertain the interaction and effects of combined reactivations of BK virus and cytomegalovirus on kidney graft function. All consecutive kidney transplant recipients (KTR) between 2003 and 2016 were included. Of 1976 patients who received a kidney transplant, 23 (1.2%) presented BKV-associated nephropathy (BKVAN). Factors independently associated with BKVAN were diabetes mellitus (odds ratios (OR) 3.895%, confidence intervals (CI) (1.4–10.5)), acute allograft rejection (OR 2.8 95%, CI (1.1–7.6)) and nephrostomy requirement (OR 4.195%, CI (1.3–13)). Cytomegalovirus infection was diagnosed in 19% of KTR patients. Recipients with BKVAN presented more frequently with cytomegalovirus (CMV) infection compared to patients without BKVAN (39% vs. 19%, p = 0.02). Acute allograft rejection (OR 2.95%, CI (1.4–2.4)) and nephrostomy requirement (OR 2.95%, CI (1.2–3)) were independently associated with CMV infection. Sixteen patients (69%) with BKVAN had graft dysfunction at one-year post-transplant and eight of them (35%) lost their graft. Patients presenting with BKVAN and graft loss presented more frequently a cytomegalovirus infection (OR 2.295%, CI (1.3–4.3)). In conclusion, we found a relation between CMV infection and graft loss in patients presenting BKVAN, suggesting that patients with CMV reactivation should be actively screened for BKV.
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spelling pubmed-84320402021-09-11 BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss Herrera, Sabina Bernal-Maurandi, Javier Cofan, Frederic Ventura, Pedro Marcos, Maria Angeles Linares, Laura Cuesta, Genoveva Diekmann, Fritz Moreno, Asunción Bodro, Marta J Clin Med Article We aimed to ascertain the interaction and effects of combined reactivations of BK virus and cytomegalovirus on kidney graft function. All consecutive kidney transplant recipients (KTR) between 2003 and 2016 were included. Of 1976 patients who received a kidney transplant, 23 (1.2%) presented BKV-associated nephropathy (BKVAN). Factors independently associated with BKVAN were diabetes mellitus (odds ratios (OR) 3.895%, confidence intervals (CI) (1.4–10.5)), acute allograft rejection (OR 2.8 95%, CI (1.1–7.6)) and nephrostomy requirement (OR 4.195%, CI (1.3–13)). Cytomegalovirus infection was diagnosed in 19% of KTR patients. Recipients with BKVAN presented more frequently with cytomegalovirus (CMV) infection compared to patients without BKVAN (39% vs. 19%, p = 0.02). Acute allograft rejection (OR 2.95%, CI (1.4–2.4)) and nephrostomy requirement (OR 2.95%, CI (1.2–3)) were independently associated with CMV infection. Sixteen patients (69%) with BKVAN had graft dysfunction at one-year post-transplant and eight of them (35%) lost their graft. Patients presenting with BKVAN and graft loss presented more frequently a cytomegalovirus infection (OR 2.295%, CI (1.3–4.3)). In conclusion, we found a relation between CMV infection and graft loss in patients presenting BKVAN, suggesting that patients with CMV reactivation should be actively screened for BKV. MDPI 2021-08-24 /pmc/articles/PMC8432040/ /pubmed/34501226 http://dx.doi.org/10.3390/jcm10173779 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Herrera, Sabina
Bernal-Maurandi, Javier
Cofan, Frederic
Ventura, Pedro
Marcos, Maria Angeles
Linares, Laura
Cuesta, Genoveva
Diekmann, Fritz
Moreno, Asunción
Bodro, Marta
BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title_full BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title_fullStr BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title_full_unstemmed BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title_short BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss
title_sort bk virus and cytomegalovirus coinfections in kidney transplantation and their impact on allograft loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432040/
https://www.ncbi.nlm.nih.gov/pubmed/34501226
http://dx.doi.org/10.3390/jcm10173779
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