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Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis

Objective: To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). Patients and methods: We performed a cross-sectional study of 80 JIA patients aged 4–15 years with 80 age- and sex-matched health...

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Autores principales: Diaz-Cordovés Rego, Gisela, Núñez-Cuadros, Esmeralda, Mena-Vázquez, Natalia, Aguado Henche, Soledad, Galindo-Zavala, Rocío, Manrique-Arija, Sara, Martín-Pedraz, Laura, Redondo-Rodríguez, Rocio, Godoy-Navarrete, Francisco Javier, Fernández-Nebro, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432058/
https://www.ncbi.nlm.nih.gov/pubmed/34501396
http://dx.doi.org/10.3390/jcm10173949
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author Diaz-Cordovés Rego, Gisela
Núñez-Cuadros, Esmeralda
Mena-Vázquez, Natalia
Aguado Henche, Soledad
Galindo-Zavala, Rocío
Manrique-Arija, Sara
Martín-Pedraz, Laura
Redondo-Rodríguez, Rocio
Godoy-Navarrete, Francisco Javier
Fernández-Nebro, Antonio
author_facet Diaz-Cordovés Rego, Gisela
Núñez-Cuadros, Esmeralda
Mena-Vázquez, Natalia
Aguado Henche, Soledad
Galindo-Zavala, Rocío
Manrique-Arija, Sara
Martín-Pedraz, Laura
Redondo-Rodríguez, Rocio
Godoy-Navarrete, Francisco Javier
Fernández-Nebro, Antonio
author_sort Diaz-Cordovés Rego, Gisela
collection PubMed
description Objective: To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). Patients and methods: We performed a cross-sectional study of 80 JIA patients aged 4–15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). Results: No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02–1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07–0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17–1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16–1.08]; p = 0.009), and physical activity (β [95% CI] = −0.22 [−5.76 to 0.29]; p = 0.031). Conclusion: Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course.
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spelling pubmed-84320582021-09-11 Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis Diaz-Cordovés Rego, Gisela Núñez-Cuadros, Esmeralda Mena-Vázquez, Natalia Aguado Henche, Soledad Galindo-Zavala, Rocío Manrique-Arija, Sara Martín-Pedraz, Laura Redondo-Rodríguez, Rocio Godoy-Navarrete, Francisco Javier Fernández-Nebro, Antonio J Clin Med Article Objective: To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). Patients and methods: We performed a cross-sectional study of 80 JIA patients aged 4–15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). Results: No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02–1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07–0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17–1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16–1.08]; p = 0.009), and physical activity (β [95% CI] = −0.22 [−5.76 to 0.29]; p = 0.031). Conclusion: Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course. MDPI 2021-08-31 /pmc/articles/PMC8432058/ /pubmed/34501396 http://dx.doi.org/10.3390/jcm10173949 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diaz-Cordovés Rego, Gisela
Núñez-Cuadros, Esmeralda
Mena-Vázquez, Natalia
Aguado Henche, Soledad
Galindo-Zavala, Rocío
Manrique-Arija, Sara
Martín-Pedraz, Laura
Redondo-Rodríguez, Rocio
Godoy-Navarrete, Francisco Javier
Fernández-Nebro, Antonio
Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title_full Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title_fullStr Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title_full_unstemmed Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title_short Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
title_sort adiposity is related to inflammatory disease activity in juvenile idiopathic arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432058/
https://www.ncbi.nlm.nih.gov/pubmed/34501396
http://dx.doi.org/10.3390/jcm10173949
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