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The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hosp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432060/ https://www.ncbi.nlm.nih.gov/pubmed/34501424 http://dx.doi.org/10.3390/jcm10173974 |
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author | Zhang, Juqian Bisson, Arnaud Boumhidi, Jad Herbert, Julien Saint Etienne, Christophe Bernard, Anne Lip, Gregory Y.H. Fauchier, Laurent |
author_facet | Zhang, Juqian Bisson, Arnaud Boumhidi, Jad Herbert, Julien Saint Etienne, Christophe Bernard, Anne Lip, Gregory Y.H. Fauchier, Laurent |
author_sort | Zhang, Juqian |
collection | PubMed |
description | Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality. |
format | Online Article Text |
id | pubmed-8432060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84320602021-09-11 The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation Zhang, Juqian Bisson, Arnaud Boumhidi, Jad Herbert, Julien Saint Etienne, Christophe Bernard, Anne Lip, Gregory Y.H. Fauchier, Laurent J Clin Med Article Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality. MDPI 2021-09-02 /pmc/articles/PMC8432060/ /pubmed/34501424 http://dx.doi.org/10.3390/jcm10173974 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Juqian Bisson, Arnaud Boumhidi, Jad Herbert, Julien Saint Etienne, Christophe Bernard, Anne Lip, Gregory Y.H. Fauchier, Laurent The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title | The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title_full | The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title_fullStr | The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title_full_unstemmed | The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title_short | The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation |
title_sort | prognosis of baseline mitral regurgitation in patients with transcatheter aortic valve implantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432060/ https://www.ncbi.nlm.nih.gov/pubmed/34501424 http://dx.doi.org/10.3390/jcm10173974 |
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