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The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation

Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hosp...

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Autores principales: Zhang, Juqian, Bisson, Arnaud, Boumhidi, Jad, Herbert, Julien, Saint Etienne, Christophe, Bernard, Anne, Lip, Gregory Y.H., Fauchier, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432060/
https://www.ncbi.nlm.nih.gov/pubmed/34501424
http://dx.doi.org/10.3390/jcm10173974
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author Zhang, Juqian
Bisson, Arnaud
Boumhidi, Jad
Herbert, Julien
Saint Etienne, Christophe
Bernard, Anne
Lip, Gregory Y.H.
Fauchier, Laurent
author_facet Zhang, Juqian
Bisson, Arnaud
Boumhidi, Jad
Herbert, Julien
Saint Etienne, Christophe
Bernard, Anne
Lip, Gregory Y.H.
Fauchier, Laurent
author_sort Zhang, Juqian
collection PubMed
description Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality.
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spelling pubmed-84320602021-09-11 The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation Zhang, Juqian Bisson, Arnaud Boumhidi, Jad Herbert, Julien Saint Etienne, Christophe Bernard, Anne Lip, Gregory Y.H. Fauchier, Laurent J Clin Med Article Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality. MDPI 2021-09-02 /pmc/articles/PMC8432060/ /pubmed/34501424 http://dx.doi.org/10.3390/jcm10173974 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Juqian
Bisson, Arnaud
Boumhidi, Jad
Herbert, Julien
Saint Etienne, Christophe
Bernard, Anne
Lip, Gregory Y.H.
Fauchier, Laurent
The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title_full The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title_fullStr The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title_full_unstemmed The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title_short The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation
title_sort prognosis of baseline mitral regurgitation in patients with transcatheter aortic valve implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432060/
https://www.ncbi.nlm.nih.gov/pubmed/34501424
http://dx.doi.org/10.3390/jcm10173974
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