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Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
This study aimed to define patients with renal cell cancer and coexisting tumor thrombus in order to address concerns regarding survival and prognostic factors after radical surgery. Several prognostic factors for overall survival (OS) were assessed in patients treated surgically at five institution...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432091/ https://www.ncbi.nlm.nih.gov/pubmed/34501296 http://dx.doi.org/10.3390/jcm10173852 |
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author | Zapała, Łukasz Sharma, Sumit Kunc, Michał Zapała, Piotr Kłącz, Jakub Korczyński, Piotr Lipowski, Michał Późniak, Michał Suchojad, Tomasz Drewa, Tomasz Matuszewski, Marcin Radziszewski, Piotr |
author_facet | Zapała, Łukasz Sharma, Sumit Kunc, Michał Zapała, Piotr Kłącz, Jakub Korczyński, Piotr Lipowski, Michał Późniak, Michał Suchojad, Tomasz Drewa, Tomasz Matuszewski, Marcin Radziszewski, Piotr |
author_sort | Zapała, Łukasz |
collection | PubMed |
description | This study aimed to define patients with renal cell cancer and coexisting tumor thrombus in order to address concerns regarding survival and prognostic factors after radical surgery. Several prognostic factors for overall survival (OS) were assessed in patients treated surgically at five institutions from 2012 to 2018. Univariate and multivariate analyses were used to determine the independent risk factors of OS. A total of 142 patients were eligible for further analysis (mean age of 64.75 years, 56% males). Most patients presented with clear cell carcinoma (95%). The Mayo stage was predominantly 0–1 (88%). Distant visceral metastases at the time of diagnosis were present in 36 patients (25%), whereas nodal metastases were present in 24 patients (16.9%). During the follow-up period (mean of 32.5 months), the 3-year OS rate reached 68.2%. The majority of patients received no adjuvant treatment (n = 107). In a multivariable model predicting OS, regional lymph node status (p < 0.001), distant metastases (p = 0.009), tumor grade (p = 0.002), duration of hospitalization (p = 0.016), and Clavien–Dindo grade (p = 0.047) were identified as independent prognostic factors. A subgroup of patients with specific clinicopathological factors may benefit most from the radical surgery, including patients without regional lymph node or distant metastases and with low tumor grades, whereas short hospitalization and low Clavien–Dindo grades represent additional independent prognostic factors. |
format | Online Article Text |
id | pubmed-8432091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84320912021-09-11 Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus Zapała, Łukasz Sharma, Sumit Kunc, Michał Zapała, Piotr Kłącz, Jakub Korczyński, Piotr Lipowski, Michał Późniak, Michał Suchojad, Tomasz Drewa, Tomasz Matuszewski, Marcin Radziszewski, Piotr J Clin Med Article This study aimed to define patients with renal cell cancer and coexisting tumor thrombus in order to address concerns regarding survival and prognostic factors after radical surgery. Several prognostic factors for overall survival (OS) were assessed in patients treated surgically at five institutions from 2012 to 2018. Univariate and multivariate analyses were used to determine the independent risk factors of OS. A total of 142 patients were eligible for further analysis (mean age of 64.75 years, 56% males). Most patients presented with clear cell carcinoma (95%). The Mayo stage was predominantly 0–1 (88%). Distant visceral metastases at the time of diagnosis were present in 36 patients (25%), whereas nodal metastases were present in 24 patients (16.9%). During the follow-up period (mean of 32.5 months), the 3-year OS rate reached 68.2%. The majority of patients received no adjuvant treatment (n = 107). In a multivariable model predicting OS, regional lymph node status (p < 0.001), distant metastases (p = 0.009), tumor grade (p = 0.002), duration of hospitalization (p = 0.016), and Clavien–Dindo grade (p = 0.047) were identified as independent prognostic factors. A subgroup of patients with specific clinicopathological factors may benefit most from the radical surgery, including patients without regional lymph node or distant metastases and with low tumor grades, whereas short hospitalization and low Clavien–Dindo grades represent additional independent prognostic factors. MDPI 2021-08-27 /pmc/articles/PMC8432091/ /pubmed/34501296 http://dx.doi.org/10.3390/jcm10173852 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zapała, Łukasz Sharma, Sumit Kunc, Michał Zapała, Piotr Kłącz, Jakub Korczyński, Piotr Lipowski, Michał Późniak, Michał Suchojad, Tomasz Drewa, Tomasz Matuszewski, Marcin Radziszewski, Piotr Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title | Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title_full | Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title_fullStr | Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title_full_unstemmed | Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title_short | Analysis of Clinicopathological Factors Influencing Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus |
title_sort | analysis of clinicopathological factors influencing survival in patients with renal cell carcinoma and venous tumor thrombus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432091/ https://www.ncbi.nlm.nih.gov/pubmed/34501296 http://dx.doi.org/10.3390/jcm10173852 |
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