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Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19

Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphop...

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Autores principales: Hayek, Salim S., Roderburg, Christoph, Blakely, Pennelope, Launius, Christopher, Eugen-Olsen, Jesper, Tacke, Frank, Ktena, Sofia, Keitel, Verena, Luedde, Mark, Giamarellos-Bourboulis, Evangelos J., Luedde, Tom, Loosen, Sven H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432103/
https://www.ncbi.nlm.nih.gov/pubmed/34501358
http://dx.doi.org/10.3390/jcm10173907
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author Hayek, Salim S.
Roderburg, Christoph
Blakely, Pennelope
Launius, Christopher
Eugen-Olsen, Jesper
Tacke, Frank
Ktena, Sofia
Keitel, Verena
Luedde, Mark
Giamarellos-Bourboulis, Evangelos J.
Luedde, Tom
Loosen, Sven H.
author_facet Hayek, Salim S.
Roderburg, Christoph
Blakely, Pennelope
Launius, Christopher
Eugen-Olsen, Jesper
Tacke, Frank
Ktena, Sofia
Keitel, Verena
Luedde, Mark
Giamarellos-Bourboulis, Evangelos J.
Luedde, Tom
Loosen, Sven H.
author_sort Hayek, Salim S.
collection PubMed
description Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable.
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spelling pubmed-84321032021-09-11 Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 Hayek, Salim S. Roderburg, Christoph Blakely, Pennelope Launius, Christopher Eugen-Olsen, Jesper Tacke, Frank Ktena, Sofia Keitel, Verena Luedde, Mark Giamarellos-Bourboulis, Evangelos J. Luedde, Tom Loosen, Sven H. J Clin Med Article Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable. MDPI 2021-08-30 /pmc/articles/PMC8432103/ /pubmed/34501358 http://dx.doi.org/10.3390/jcm10173907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hayek, Salim S.
Roderburg, Christoph
Blakely, Pennelope
Launius, Christopher
Eugen-Olsen, Jesper
Tacke, Frank
Ktena, Sofia
Keitel, Verena
Luedde, Mark
Giamarellos-Bourboulis, Evangelos J.
Luedde, Tom
Loosen, Sven H.
Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title_full Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title_fullStr Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title_full_unstemmed Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title_short Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
title_sort circulating osteopontin levels and outcomes in patients hospitalized for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432103/
https://www.ncbi.nlm.nih.gov/pubmed/34501358
http://dx.doi.org/10.3390/jcm10173907
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