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Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19
Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphop...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432103/ https://www.ncbi.nlm.nih.gov/pubmed/34501358 http://dx.doi.org/10.3390/jcm10173907 |
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author | Hayek, Salim S. Roderburg, Christoph Blakely, Pennelope Launius, Christopher Eugen-Olsen, Jesper Tacke, Frank Ktena, Sofia Keitel, Verena Luedde, Mark Giamarellos-Bourboulis, Evangelos J. Luedde, Tom Loosen, Sven H. |
author_facet | Hayek, Salim S. Roderburg, Christoph Blakely, Pennelope Launius, Christopher Eugen-Olsen, Jesper Tacke, Frank Ktena, Sofia Keitel, Verena Luedde, Mark Giamarellos-Bourboulis, Evangelos J. Luedde, Tom Loosen, Sven H. |
author_sort | Hayek, Salim S. |
collection | PubMed |
description | Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable. |
format | Online Article Text |
id | pubmed-8432103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84321032021-09-11 Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 Hayek, Salim S. Roderburg, Christoph Blakely, Pennelope Launius, Christopher Eugen-Olsen, Jesper Tacke, Frank Ktena, Sofia Keitel, Verena Luedde, Mark Giamarellos-Bourboulis, Evangelos J. Luedde, Tom Loosen, Sven H. J Clin Med Article Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteopontin (OPN) is an integrin-binding glyco-phosphoprotein involved in the modulation of leukocyte activation; its levels are associated with worse outcomes in patients with sepsis. Whether OPN levels predict outcomes in COVID-19 is unknown. Methods: We measured OPN levels in serum of 341 hospitalized COVID-19 patients collected within 48 h from admission. We characterized the determinants of OPN levels and examined their association with in-hospital outcomes; notably death, need for mechanical ventilation, and need for renal replacement therapy (RRT) and as a composite outcome. The risk discrimination ability of OPN was compared with other inflammatory biomarkers. Results: Patients with COVID-19 (mean age 60, 61.9% male, 27.0% blacks) had significantly higher levels of serum OPN compared to healthy volunteers (96.63 vs. 16.56 ng/mL, p < 0.001). Overall, 104 patients required mechanical ventilation, 35 needed dialysis, and 53 died during their hospitalization. In multivariable analyses, OPN levels ≥140.66 ng/mL (third tertile) were associated with a 3.5 × (95%CI 1.44–8.27) increase in the odds of death, and 4.9 × (95%CI 2.48–9.80) increase in the odds of requiring mechanical ventilation. There was no association between OPN and need for RRT. Finally, OPN levels in the upper tertile turned out as an independent prognostic factor of event-free survival with respect to the composite endpoint. Conclusion: Higher OPN levels are associated with increased odds of death and mechanical ventilation in patients with COVID-19, however, their utility in triage is questionable. MDPI 2021-08-30 /pmc/articles/PMC8432103/ /pubmed/34501358 http://dx.doi.org/10.3390/jcm10173907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hayek, Salim S. Roderburg, Christoph Blakely, Pennelope Launius, Christopher Eugen-Olsen, Jesper Tacke, Frank Ktena, Sofia Keitel, Verena Luedde, Mark Giamarellos-Bourboulis, Evangelos J. Luedde, Tom Loosen, Sven H. Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title | Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title_full | Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title_fullStr | Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title_full_unstemmed | Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title_short | Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19 |
title_sort | circulating osteopontin levels and outcomes in patients hospitalized for covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432103/ https://www.ncbi.nlm.nih.gov/pubmed/34501358 http://dx.doi.org/10.3390/jcm10173907 |
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