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Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver

Considering that some biliary atresia (BA) survivors with native liver have reached reproductive age and face long-lasting complications, specific attention needs to be paid to pregnant cases. This study aimed to investigate the relationship between liver function, perinatal outcomes, and prognosis....

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Autores principales: Takahashi, Nobuhiro, Ochiai, Daigo, Yamada, Yohei, Tamagawa, Masumi, Kanamori, Hiroki, Kato, Mototoshi, Ikenoue, Satoru, Kasuga, Yoshifumi, Kuroda, Tatsuo, Tanaka, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432127/
https://www.ncbi.nlm.nih.gov/pubmed/34501403
http://dx.doi.org/10.3390/jcm10173956
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author Takahashi, Nobuhiro
Ochiai, Daigo
Yamada, Yohei
Tamagawa, Masumi
Kanamori, Hiroki
Kato, Mototoshi
Ikenoue, Satoru
Kasuga, Yoshifumi
Kuroda, Tatsuo
Tanaka, Mamoru
author_facet Takahashi, Nobuhiro
Ochiai, Daigo
Yamada, Yohei
Tamagawa, Masumi
Kanamori, Hiroki
Kato, Mototoshi
Ikenoue, Satoru
Kasuga, Yoshifumi
Kuroda, Tatsuo
Tanaka, Mamoru
author_sort Takahashi, Nobuhiro
collection PubMed
description Considering that some biliary atresia (BA) survivors with native liver have reached reproductive age and face long-lasting complications, specific attention needs to be paid to pregnant cases. This study aimed to investigate the relationship between liver function, perinatal outcomes, and prognosis. A database review was conducted to identify pregnant BA cases with native liver and perinatal data, and clinical information on BA-related complications was analyzed. Perinatal serum cholinesterase (ChE) levels, model for end-stage liver-disease (MELD) score, and platelet trends were analyzed, and the association between these indicators and perinatal outcomes was investigated. Patients were categorized into three groups according to the perinatal clinical outcomes: favorable (term babies with or without several episodes of cholangitis; n = 3), borderline (term baby and following liver dysfunction; n = 1), and unfavorable (premature delivery with subsequent liver failure; n = 1). Lower serum ChE levels, lower platelet counts, and higher MELD scores were observed in the unfavorable category. Borderline and unfavorable patients displayed a continuous increase in MELD score, with one eventually needing a liver transplantation. Pregnancy in patients with BA requires special attention. Serum ChE levels, platelet counts, and MELD scores are all important markers for predicting perinatal prognosis.
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spelling pubmed-84321272021-09-11 Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver Takahashi, Nobuhiro Ochiai, Daigo Yamada, Yohei Tamagawa, Masumi Kanamori, Hiroki Kato, Mototoshi Ikenoue, Satoru Kasuga, Yoshifumi Kuroda, Tatsuo Tanaka, Mamoru J Clin Med Brief Report Considering that some biliary atresia (BA) survivors with native liver have reached reproductive age and face long-lasting complications, specific attention needs to be paid to pregnant cases. This study aimed to investigate the relationship between liver function, perinatal outcomes, and prognosis. A database review was conducted to identify pregnant BA cases with native liver and perinatal data, and clinical information on BA-related complications was analyzed. Perinatal serum cholinesterase (ChE) levels, model for end-stage liver-disease (MELD) score, and platelet trends were analyzed, and the association between these indicators and perinatal outcomes was investigated. Patients were categorized into three groups according to the perinatal clinical outcomes: favorable (term babies with or without several episodes of cholangitis; n = 3), borderline (term baby and following liver dysfunction; n = 1), and unfavorable (premature delivery with subsequent liver failure; n = 1). Lower serum ChE levels, lower platelet counts, and higher MELD scores were observed in the unfavorable category. Borderline and unfavorable patients displayed a continuous increase in MELD score, with one eventually needing a liver transplantation. Pregnancy in patients with BA requires special attention. Serum ChE levels, platelet counts, and MELD scores are all important markers for predicting perinatal prognosis. MDPI 2021-08-31 /pmc/articles/PMC8432127/ /pubmed/34501403 http://dx.doi.org/10.3390/jcm10173956 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Takahashi, Nobuhiro
Ochiai, Daigo
Yamada, Yohei
Tamagawa, Masumi
Kanamori, Hiroki
Kato, Mototoshi
Ikenoue, Satoru
Kasuga, Yoshifumi
Kuroda, Tatsuo
Tanaka, Mamoru
Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title_full Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title_fullStr Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title_full_unstemmed Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title_short Prepregnancy Assessment of Liver Function to Predict Perinatal and Postpregnancy Outcomes in Biliary Atresia Patients with Native Liver
title_sort prepregnancy assessment of liver function to predict perinatal and postpregnancy outcomes in biliary atresia patients with native liver
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432127/
https://www.ncbi.nlm.nih.gov/pubmed/34501403
http://dx.doi.org/10.3390/jcm10173956
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