H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours

Diagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable...

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Detalles Bibliográficos
Autores principales: Lyskjær, Iben, Lindsay, Daniel, Tirabosco, Roberto, Steele, Christopher D, Lombard, Patrick, Strobl, Anna‐Christina, Rocha, Ana M, Davies, Christopher, Ye, Hongtao, Bekers, Elise, Ingruber, Julia, Lechner, Matt, Amary, Fernanda, Pillay, Nischalan, Flanagan, Adrienne M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432159/
https://www.ncbi.nlm.nih.gov/pubmed/32666581
http://dx.doi.org/10.1002/path.5507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432159/
https://www.ncbi.nlm.nih.gov/pubmed/32666581
http://dx.doi.org/10.1002/path.5507

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