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H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours
Diagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable...
Autores principales: | Lyskjær, Iben, Lindsay, Daniel, Tirabosco, Roberto, Steele, Christopher D, Lombard, Patrick, Strobl, Anna‐Christina, Rocha, Ana M, Davies, Christopher, Ye, Hongtao, Bekers, Elise, Ingruber, Julia, Lechner, Matt, Amary, Fernanda, Pillay, Nischalan, Flanagan, Adrienne M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432159/ https://www.ncbi.nlm.nih.gov/pubmed/32666581 http://dx.doi.org/10.1002/path.5507 |
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