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Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies

Pooled gastric residues involving blood clots and food interrupt appropriate endoscopic intervention, leading to poor outcomes in endoscopic hemostasis and lifesaving. However, procedures and devices that enable the effective removal of gastrointestinal residues remain unsatisfactory. This study aim...

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Autores principales: Kozuka, Kazuhiro, Kobara, Hideki, Nishiyama, Noriko, Fujihara, Shintaro, Tada, Naoya, Matsui, Takanori, Takata, Tadayuki, Chiyo, Taiga, Kobayashi, Nobuya, Shi, Tingting, Fujita, Koji, Tani, Joji, Yachida, Tatsuo, Kondo, Akihiro, Kumamoto, Kensuke, Okano, Keiichi, Nishiyama, Akira, Deguchi, Kazushi, Masaki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432193/
https://www.ncbi.nlm.nih.gov/pubmed/34501244
http://dx.doi.org/10.3390/jcm10173796
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author Kozuka, Kazuhiro
Kobara, Hideki
Nishiyama, Noriko
Fujihara, Shintaro
Tada, Naoya
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Kondo, Akihiro
Kumamoto, Kensuke
Okano, Keiichi
Nishiyama, Akira
Deguchi, Kazushi
Masaki, Tsutomu
author_facet Kozuka, Kazuhiro
Kobara, Hideki
Nishiyama, Noriko
Fujihara, Shintaro
Tada, Naoya
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Kondo, Akihiro
Kumamoto, Kensuke
Okano, Keiichi
Nishiyama, Akira
Deguchi, Kazushi
Masaki, Tsutomu
author_sort Kozuka, Kazuhiro
collection PubMed
description Pooled gastric residues involving blood clots and food interrupt appropriate endoscopic intervention, leading to poor outcomes in endoscopic hemostasis and lifesaving. However, procedures and devices that enable the effective removal of gastrointestinal residues remain unsatisfactory. This study aimed to evaluate the efficacy and safety of our developed suction method in ex vivo and in vivo studies. We created a hand-made device with a large suction diameter, consisting of a balloon overtube and an ultrathin endoscope for navigation. In the ex vivo study, we compared the success rate and the suctioning time for four types of simulated residue between a standard endoscope and our device. Our device had s significantly higher suction ability and a shorter procedure time than the standard endoscope. The subsequent in vivo animal study involved five beagle dogs that were administered with food jelly to mimic gastric residue. Suction was performed twice for five dogs (ten attempts). The outcome measure was the successful procedure rate; secondary outcomes were procedure-associated complications and procedure time. The procedure was successful in all attempts, without any complications. The mean procedure time was 5 min. This novel method enabled the efficient and safe removal of gastric residue, and our findings will likely lead to the development of the instrument.
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spelling pubmed-84321932021-09-11 Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies Kozuka, Kazuhiro Kobara, Hideki Nishiyama, Noriko Fujihara, Shintaro Tada, Naoya Matsui, Takanori Takata, Tadayuki Chiyo, Taiga Kobayashi, Nobuya Shi, Tingting Fujita, Koji Tani, Joji Yachida, Tatsuo Kondo, Akihiro Kumamoto, Kensuke Okano, Keiichi Nishiyama, Akira Deguchi, Kazushi Masaki, Tsutomu J Clin Med Article Pooled gastric residues involving blood clots and food interrupt appropriate endoscopic intervention, leading to poor outcomes in endoscopic hemostasis and lifesaving. However, procedures and devices that enable the effective removal of gastrointestinal residues remain unsatisfactory. This study aimed to evaluate the efficacy and safety of our developed suction method in ex vivo and in vivo studies. We created a hand-made device with a large suction diameter, consisting of a balloon overtube and an ultrathin endoscope for navigation. In the ex vivo study, we compared the success rate and the suctioning time for four types of simulated residue between a standard endoscope and our device. Our device had s significantly higher suction ability and a shorter procedure time than the standard endoscope. The subsequent in vivo animal study involved five beagle dogs that were administered with food jelly to mimic gastric residue. Suction was performed twice for five dogs (ten attempts). The outcome measure was the successful procedure rate; secondary outcomes were procedure-associated complications and procedure time. The procedure was successful in all attempts, without any complications. The mean procedure time was 5 min. This novel method enabled the efficient and safe removal of gastric residue, and our findings will likely lead to the development of the instrument. MDPI 2021-08-25 /pmc/articles/PMC8432193/ /pubmed/34501244 http://dx.doi.org/10.3390/jcm10173796 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozuka, Kazuhiro
Kobara, Hideki
Nishiyama, Noriko
Fujihara, Shintaro
Tada, Naoya
Matsui, Takanori
Takata, Tadayuki
Chiyo, Taiga
Kobayashi, Nobuya
Shi, Tingting
Fujita, Koji
Tani, Joji
Yachida, Tatsuo
Kondo, Akihiro
Kumamoto, Kensuke
Okano, Keiichi
Nishiyama, Akira
Deguchi, Kazushi
Masaki, Tsutomu
Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title_full Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title_fullStr Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title_full_unstemmed Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title_short Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies
title_sort gastrointestinal residue removal using a balloon overtube under ultrathin endoscopic navigation: ex vivo and in vivo experimental studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432193/
https://www.ncbi.nlm.nih.gov/pubmed/34501244
http://dx.doi.org/10.3390/jcm10173796
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