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Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C

The effectiveness of interferon-free therapy during the course of HCV infection has already been confirmed. Liver fibrosis can be assessed in several ways, from biopsies to imaging tests. The present study evaluates the usefulness of non-invasive indirect biomarkers of liver fibrosis (APRI, GAPRI, F...

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Autores principales: Przekop, Dagmara, Klapaczynski, Jakub, Grytczuk, Agnieszka, Gruszewska, Ewa, Gietka, Andrzej, Panasiuk, Anatol, Golaszewski, Slawomir, Cylwik, Bogdan, Chrostek, Lech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432198/
https://www.ncbi.nlm.nih.gov/pubmed/34501398
http://dx.doi.org/10.3390/jcm10173951
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author Przekop, Dagmara
Klapaczynski, Jakub
Grytczuk, Agnieszka
Gruszewska, Ewa
Gietka, Andrzej
Panasiuk, Anatol
Golaszewski, Slawomir
Cylwik, Bogdan
Chrostek, Lech
author_facet Przekop, Dagmara
Klapaczynski, Jakub
Grytczuk, Agnieszka
Gruszewska, Ewa
Gietka, Andrzej
Panasiuk, Anatol
Golaszewski, Slawomir
Cylwik, Bogdan
Chrostek, Lech
author_sort Przekop, Dagmara
collection PubMed
description The effectiveness of interferon-free therapy during the course of HCV infection has already been confirmed. Liver fibrosis can be assessed in several ways, from biopsies to imaging tests. The present study evaluates the usefulness of non-invasive indirect biomarkers of liver fibrosis (APRI, GAPRI, FORNS, FIB-4, the AP index and HUI score) as markers of the effective treatment of HCV with the 3D regimen. Blood samples were collected from 70 patients suffering from chronic hepatitis C. Patients received the 3D AbbVie regimen for hepatitis C. All patients had HCV genotype 1b. The APRI, GAPRI, FIB-4, FORNS, HUI and AP index (age–platelet score) values were calculated with their respective algorithms. The stage of fibrosis was evaluated on the basis of a liver biopsy and confirmed by FibroScan-based transient elastography. An undetectable level of HCV RNA after 12 weeks of treatment with the 3D regimen indicates 100% eradication of hepatitis C virus. After the treatment, non-invasive indirect markers of liver fibrosis achieved levels below the limit for significant fibrosis, Thus, non-invasive indirect biomarkers of hepatic fibrosis failed to detect the presence of significant fibrosis, which was proved in histopathological examination. However, the eradication of hepatitis C virus by means of the 3D regimen treatment does not mean that patients were completely cured.
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spelling pubmed-84321982021-09-11 Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C Przekop, Dagmara Klapaczynski, Jakub Grytczuk, Agnieszka Gruszewska, Ewa Gietka, Andrzej Panasiuk, Anatol Golaszewski, Slawomir Cylwik, Bogdan Chrostek, Lech J Clin Med Article The effectiveness of interferon-free therapy during the course of HCV infection has already been confirmed. Liver fibrosis can be assessed in several ways, from biopsies to imaging tests. The present study evaluates the usefulness of non-invasive indirect biomarkers of liver fibrosis (APRI, GAPRI, FORNS, FIB-4, the AP index and HUI score) as markers of the effective treatment of HCV with the 3D regimen. Blood samples were collected from 70 patients suffering from chronic hepatitis C. Patients received the 3D AbbVie regimen for hepatitis C. All patients had HCV genotype 1b. The APRI, GAPRI, FIB-4, FORNS, HUI and AP index (age–platelet score) values were calculated with their respective algorithms. The stage of fibrosis was evaluated on the basis of a liver biopsy and confirmed by FibroScan-based transient elastography. An undetectable level of HCV RNA after 12 weeks of treatment with the 3D regimen indicates 100% eradication of hepatitis C virus. After the treatment, non-invasive indirect markers of liver fibrosis achieved levels below the limit for significant fibrosis, Thus, non-invasive indirect biomarkers of hepatic fibrosis failed to detect the presence of significant fibrosis, which was proved in histopathological examination. However, the eradication of hepatitis C virus by means of the 3D regimen treatment does not mean that patients were completely cured. MDPI 2021-08-31 /pmc/articles/PMC8432198/ /pubmed/34501398 http://dx.doi.org/10.3390/jcm10173951 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Przekop, Dagmara
Klapaczynski, Jakub
Grytczuk, Agnieszka
Gruszewska, Ewa
Gietka, Andrzej
Panasiuk, Anatol
Golaszewski, Slawomir
Cylwik, Bogdan
Chrostek, Lech
Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title_full Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title_fullStr Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title_full_unstemmed Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title_short Non-Invasive Indirect Markers of Liver Fibrosis after Interferon-Free Treatment for Hepatitis C
title_sort non-invasive indirect markers of liver fibrosis after interferon-free treatment for hepatitis c
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432198/
https://www.ncbi.nlm.nih.gov/pubmed/34501398
http://dx.doi.org/10.3390/jcm10173951
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