Cargando…

FMR1 and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response

We aimed to determine whether a functional link with impact on female ovarian reserve exists between FMR1 expression and expression ratios of AKT/mTOR signaling genes in human granulosa cells in vivo, as suggested from prior in vitro data. Three hundred and nine women, who were classified as normal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rehnitz, Julia, Capp, Edison, Messmer, Birgitta, Nguyen, Xuan Phuoc, Germeyer, Ariane, Freis, Alexander, Dietrich, Jens Erik, Hinderhofer, Karin, Strowitzki, Thomas, Vogt, Peter H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432207/ https://www.ncbi.nlm.nih.gov/pubmed/34501340 http://dx.doi.org/10.3390/jcm10173892

Ejemplares similares

Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression
por: Rehnitz, Julia, et al.
Publicado: (2022)

FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve
por: Rehnitz, Julia, et al.
Publicado: (2018)

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients
por: Rehnitz, Julia, et al.
Publicado: (2020)

Expression of FMRpolyG in Peripheral Blood Mononuclear Cells of Women with Fragile X Mental Retardation 1 Gene Premutation
por: Nguyen, Xuan Phuoc, et al.
Publicado: (2022)

Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study
por: Freis, Alexander, et al.
Publicado: (2018)

Intraindividual Embryo Morphokinetics Are Not Affected by a Switch of the Ovarian Stimulation Protocol Between GnRH Agonist vs. Antagonist Regimens in Consecutive Cycles
por: Dietrich, Jens E., et al.
Publicado: (2020)

GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium – potential biomarkers in the detection of endometriosis – a pilot study
por: Holzer, Isabell, et al.
Publicado: (2020)

Serum periostin levels in early in pregnancy are significantly altered in women with miscarriage
por: Freis, A., et al.
Publicado: (2017)

FMRpolyG accumulates in FMR1 premutation granulosa cells
por: Friedman-Gohas, M., et al.
Publicado: (2020)

Decreased Autophagy Impairs Decidualization of Human Endometrial Stromal Cells: A Role for ATG Proteins in Endometrial Physiology
por: Mestre Citrinovitz, Ana Cecilia, et al.
Publicado: (2019)

Patient- and cycle-specific factors affecting the outcome of frozen–thawed embryo transfers
por: Holschbach, Verena, et al.
Publicado: (2023)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation
por: Yu, James, et al.
Publicado: (2011)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Elevated Levels of FMR1 mRNA in Granulosa Cells Are Associated with Low Ovarian Reserve in FMR1 Premutation Carriers
por: Elizur, Shai E., et al.
Publicado: (2014)

Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways
por: Zhu, Yifeng, et al.
Publicado: (2021)

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin
por: Mok-Lin, E., et al.
Publicado: (2018)

Lysophosphatidic acid is associated with oocyte maturation by enhancing autophagy via PI3K-AKT-mTOR signaling pathway in granulosa cells
por: Liu, Jia, et al.
Publicado: (2023)

Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling
por: Zhang, Xiaodan, et al.
Publicado: (2022)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Changes in the expression of cancer- and metastasis-related genes and proteins after metformin treatment under different metabolic conditions in endometrial cancer cells
por: Lange, Carsten, et al.
Publicado: (2023)

Plumbagin inhibits proliferation and promotes apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inactivating PI3K/Akt/mTOR pathway
por: Cai, Zhaowei, et al.
Publicado: (2020)

Melatonin regulates chicken granulosa cell proliferation and apoptosis by activating the mTOR signaling pathway via its receptors
por: Hao, Er-ying, et al.
Publicado: (2020)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line
por: Lange, Carsten, et al.
Publicado: (2021)

Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway
por: Fan, Huiying, et al.
Publicado: (2022)

Catalpol protects rat ovarian granulosa cells against oxidative stress and apoptosis through modulating the PI3K/Akt/mTOR signaling pathway
por: Yan, Jin, et al.
Publicado: (2020)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

BSCI-11. Targeting PI3K/Akt/mTOR pathway to prevent melanoma brain metastasis
por: Tehranian, Cedric, et al.
Publicado: (2021)

Changes in cell proliferation, but not in vascularisation are characteristic for human endometrium in different reproductive failures - a pilot study
por: Germeyer, Ariane, et al.
Publicado: (2010)

Dysregulation of anti-Mullerian hormone expression levels in mural granulosa cells of FMR1 premutation carriers
por: Friedman-Gohas, Moran, et al.
Publicado: (2021)

The AMPK-mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis
por: Liu, Xuejie, et al.
Publicado: (2021)

Targeting PI3K/Akt/mTOR Signaling in Cancer
por: Porta, Camillo, et al.
Publicado: (2014)

PI3K/Akt/mTOR inhibitors in breast cancer
por: Lee, Joycelyn JX, et al.
Publicado: (2015)

Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder
por: Onore, Charity, et al.
Publicado: (2017)

The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling
por: Zhang, Ruohan, et al.
Publicado: (2022)

mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines
por: Freis, Patricia, et al.
Publicado: (2017)

Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis
por: Zhao, Jia-Xing, et al.
Publicado: (2017)

lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure
por: Bao, Dongqin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t8s5d65jgqv5r6gcvog555o954