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Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation

Background: Atrial fibrillation (AF) leads to the development of cardiac remodeling/diastolic dysfunction and vice versa. We intended to determine whether cardiac remodeling/diastolic dysfunction is present at early stages of AF. Methods: We studied 175 patients with paroxysmal AF, compared with 175...

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Autores principales: Noirclerc, Nathalie, Huttin, Olivier, de Chillou, Christian, Selton-Suty, Christine, Fillipetti, Laura, Sellal, Jean Marc, Bozec, Erwan, Donal, Erwan, Lamiral, Zohra, Kobayashi, Masatake, Ferreira, João Pedro, Rossignol, Patrick, Girerd, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432208/
https://www.ncbi.nlm.nih.gov/pubmed/34501342
http://dx.doi.org/10.3390/jcm10173894
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author Noirclerc, Nathalie
Huttin, Olivier
de Chillou, Christian
Selton-Suty, Christine
Fillipetti, Laura
Sellal, Jean Marc
Bozec, Erwan
Donal, Erwan
Lamiral, Zohra
Kobayashi, Masatake
Ferreira, João Pedro
Rossignol, Patrick
Girerd, Nicolas
author_facet Noirclerc, Nathalie
Huttin, Olivier
de Chillou, Christian
Selton-Suty, Christine
Fillipetti, Laura
Sellal, Jean Marc
Bozec, Erwan
Donal, Erwan
Lamiral, Zohra
Kobayashi, Masatake
Ferreira, João Pedro
Rossignol, Patrick
Girerd, Nicolas
author_sort Noirclerc, Nathalie
collection PubMed
description Background: Atrial fibrillation (AF) leads to the development of cardiac remodeling/diastolic dysfunction and vice versa. We intended to determine whether cardiac remodeling/diastolic dysfunction is present at early stages of AF. Methods: We studied 175 patients with paroxysmal AF, compared with 175 matched control subjects, who had available echocardiography data to investigate the association between echocardiographic variables and AF from the STANISLAS cohort. Results: In this study (mean age 55 years; 70.3% male), patients with paroxysmal AF had greater left ventricular mass compared to matched controls (p < 0.05). Patients with paroxysmal AF were also likely to have larger left atrial volume and a higher peak tricuspid regurgitation velocity, leading to higher prevalence (though <10% in the AF group) of diastolic dysfunction (all-p < 0.05). Multivariable conditional logistic regression models showed that paroxysmal AF was significantly associated with increased left ventricular mass and left atrial enlargement (all-p < 0.001), but not with e’ and deceleration time of E wave (all-p > 0.1). Conclusions: Left ventricular mass and left atrial enlargement rather than diastolic dysfunction (as evaluated by echocardiography) were associated with paroxysmal AF irrespective of body mass index, blood pressure and renal function. These findings suggest that cardiac remodeling may occur very early in the natural history of AF.
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spelling pubmed-84322082021-09-11 Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation Noirclerc, Nathalie Huttin, Olivier de Chillou, Christian Selton-Suty, Christine Fillipetti, Laura Sellal, Jean Marc Bozec, Erwan Donal, Erwan Lamiral, Zohra Kobayashi, Masatake Ferreira, João Pedro Rossignol, Patrick Girerd, Nicolas J Clin Med Brief Report Background: Atrial fibrillation (AF) leads to the development of cardiac remodeling/diastolic dysfunction and vice versa. We intended to determine whether cardiac remodeling/diastolic dysfunction is present at early stages of AF. Methods: We studied 175 patients with paroxysmal AF, compared with 175 matched control subjects, who had available echocardiography data to investigate the association between echocardiographic variables and AF from the STANISLAS cohort. Results: In this study (mean age 55 years; 70.3% male), patients with paroxysmal AF had greater left ventricular mass compared to matched controls (p < 0.05). Patients with paroxysmal AF were also likely to have larger left atrial volume and a higher peak tricuspid regurgitation velocity, leading to higher prevalence (though <10% in the AF group) of diastolic dysfunction (all-p < 0.05). Multivariable conditional logistic regression models showed that paroxysmal AF was significantly associated with increased left ventricular mass and left atrial enlargement (all-p < 0.001), but not with e’ and deceleration time of E wave (all-p > 0.1). Conclusions: Left ventricular mass and left atrial enlargement rather than diastolic dysfunction (as evaluated by echocardiography) were associated with paroxysmal AF irrespective of body mass index, blood pressure and renal function. These findings suggest that cardiac remodeling may occur very early in the natural history of AF. MDPI 2021-08-30 /pmc/articles/PMC8432208/ /pubmed/34501342 http://dx.doi.org/10.3390/jcm10173894 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Noirclerc, Nathalie
Huttin, Olivier
de Chillou, Christian
Selton-Suty, Christine
Fillipetti, Laura
Sellal, Jean Marc
Bozec, Erwan
Donal, Erwan
Lamiral, Zohra
Kobayashi, Masatake
Ferreira, João Pedro
Rossignol, Patrick
Girerd, Nicolas
Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title_full Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title_fullStr Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title_full_unstemmed Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title_short Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation
title_sort cardiac remodeling and diastolic dysfunction in paroxysmal atrial fibrillation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432208/
https://www.ncbi.nlm.nih.gov/pubmed/34501342
http://dx.doi.org/10.3390/jcm10173894
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