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First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432220/ https://www.ncbi.nlm.nih.gov/pubmed/34501262 http://dx.doi.org/10.3390/jcm10173814 |
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author | Buerger, Olga Elger, Tania Varthaliti, Antonia Syngelaki, Argyro Wright, Alan Nicolaides, Kypros H. |
author_facet | Buerger, Olga Elger, Tania Varthaliti, Antonia Syngelaki, Argyro Wright, Alan Nicolaides, Kypros H. |
author_sort | Buerger, Olga |
collection | PubMed |
description | We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin pregnancies. We found the respective odds of GDM in dichorionic and monochorionic twin pregnancies to be 1.36 (95% CI: 1.02–1.81) and 2.78 (95% CI: 1.72–4.48) times higher than in singleton pregnancies. In both singleton and twin pregnancies, the risk for GDM increased with maternal age and weight and birth weight z-score of a baby in a previous pregnancy and is higher in women with a previous pregnancy complicated by GDM; in those with a first- or second-degree relative with diabetes mellitus; in women of Black, East Asian, and South Asian racial origin; and in pregnancies conceived through the use of ovulation-induction drugs. In singleton pregnancies, at 10% and 20% false-positive rate, the detection rate was 43% and 58%, respectively. In twin pregnancies, using risk cut-offs corresponding to 10% and 20% false-positive rates in singletons, the respective false-positive rates were 27% and 47%, and the detection rates were 63% and 81%. |
format | Online Article Text |
id | pubmed-8432220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84322202021-09-11 First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies Buerger, Olga Elger, Tania Varthaliti, Antonia Syngelaki, Argyro Wright, Alan Nicolaides, Kypros H. J Clin Med Article We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin pregnancies. We found the respective odds of GDM in dichorionic and monochorionic twin pregnancies to be 1.36 (95% CI: 1.02–1.81) and 2.78 (95% CI: 1.72–4.48) times higher than in singleton pregnancies. In both singleton and twin pregnancies, the risk for GDM increased with maternal age and weight and birth weight z-score of a baby in a previous pregnancy and is higher in women with a previous pregnancy complicated by GDM; in those with a first- or second-degree relative with diabetes mellitus; in women of Black, East Asian, and South Asian racial origin; and in pregnancies conceived through the use of ovulation-induction drugs. In singleton pregnancies, at 10% and 20% false-positive rate, the detection rate was 43% and 58%, respectively. In twin pregnancies, using risk cut-offs corresponding to 10% and 20% false-positive rates in singletons, the respective false-positive rates were 27% and 47%, and the detection rates were 63% and 81%. MDPI 2021-08-25 /pmc/articles/PMC8432220/ /pubmed/34501262 http://dx.doi.org/10.3390/jcm10173814 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Buerger, Olga Elger, Tania Varthaliti, Antonia Syngelaki, Argyro Wright, Alan Nicolaides, Kypros H. First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title | First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title_full | First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title_fullStr | First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title_full_unstemmed | First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title_short | First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies |
title_sort | first-trimester screening for gestational diabetes mellitus in twin pregnancies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432220/ https://www.ncbi.nlm.nih.gov/pubmed/34501262 http://dx.doi.org/10.3390/jcm10173814 |
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