Cargando…

First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies

We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin p...

Descripción completa

Detalles Bibliográficos
Autores principales: Buerger, Olga, Elger, Tania, Varthaliti, Antonia, Syngelaki, Argyro, Wright, Alan, Nicolaides, Kypros H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432220/
https://www.ncbi.nlm.nih.gov/pubmed/34501262
http://dx.doi.org/10.3390/jcm10173814
_version_ 1783751113620586496
author Buerger, Olga
Elger, Tania
Varthaliti, Antonia
Syngelaki, Argyro
Wright, Alan
Nicolaides, Kypros H.
author_facet Buerger, Olga
Elger, Tania
Varthaliti, Antonia
Syngelaki, Argyro
Wright, Alan
Nicolaides, Kypros H.
author_sort Buerger, Olga
collection PubMed
description We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin pregnancies. We found the respective odds of GDM in dichorionic and monochorionic twin pregnancies to be 1.36 (95% CI: 1.02–1.81) and 2.78 (95% CI: 1.72–4.48) times higher than in singleton pregnancies. In both singleton and twin pregnancies, the risk for GDM increased with maternal age and weight and birth weight z-score of a baby in a previous pregnancy and is higher in women with a previous pregnancy complicated by GDM; in those with a first- or second-degree relative with diabetes mellitus; in women of Black, East Asian, and South Asian racial origin; and in pregnancies conceived through the use of ovulation-induction drugs. In singleton pregnancies, at 10% and 20% false-positive rate, the detection rate was 43% and 58%, respectively. In twin pregnancies, using risk cut-offs corresponding to 10% and 20% false-positive rates in singletons, the respective false-positive rates were 27% and 47%, and the detection rates were 63% and 81%.
format Online
Article
Text
id pubmed-8432220
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84322202021-09-11 First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies Buerger, Olga Elger, Tania Varthaliti, Antonia Syngelaki, Argyro Wright, Alan Nicolaides, Kypros H. J Clin Med Article We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin pregnancies. We found the respective odds of GDM in dichorionic and monochorionic twin pregnancies to be 1.36 (95% CI: 1.02–1.81) and 2.78 (95% CI: 1.72–4.48) times higher than in singleton pregnancies. In both singleton and twin pregnancies, the risk for GDM increased with maternal age and weight and birth weight z-score of a baby in a previous pregnancy and is higher in women with a previous pregnancy complicated by GDM; in those with a first- or second-degree relative with diabetes mellitus; in women of Black, East Asian, and South Asian racial origin; and in pregnancies conceived through the use of ovulation-induction drugs. In singleton pregnancies, at 10% and 20% false-positive rate, the detection rate was 43% and 58%, respectively. In twin pregnancies, using risk cut-offs corresponding to 10% and 20% false-positive rates in singletons, the respective false-positive rates were 27% and 47%, and the detection rates were 63% and 81%. MDPI 2021-08-25 /pmc/articles/PMC8432220/ /pubmed/34501262 http://dx.doi.org/10.3390/jcm10173814 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buerger, Olga
Elger, Tania
Varthaliti, Antonia
Syngelaki, Argyro
Wright, Alan
Nicolaides, Kypros H.
First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title_full First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title_fullStr First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title_full_unstemmed First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title_short First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies
title_sort first-trimester screening for gestational diabetes mellitus in twin pregnancies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432220/
https://www.ncbi.nlm.nih.gov/pubmed/34501262
http://dx.doi.org/10.3390/jcm10173814
work_keys_str_mv AT buergerolga firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies
AT elgertania firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies
AT varthalitiantonia firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies
AT syngelakiargyro firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies
AT wrightalan firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies
AT nicolaideskyprosh firsttrimesterscreeningforgestationaldiabetesmellitusintwinpregnancies