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PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics

The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document,...

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Autores principales: Zubiaur, Pablo, Mejía-Abril, Gina, Navares-Gómez, Marcos, Villapalos-García, Gonzalo, Soria-Chacartegui, Paula, Saiz-Rodríguez, Miriam, Ochoa, Dolores, Abad-Santos, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432257/
https://www.ncbi.nlm.nih.gov/pubmed/34501219
http://dx.doi.org/10.3390/jcm10173772
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author Zubiaur, Pablo
Mejía-Abril, Gina
Navares-Gómez, Marcos
Villapalos-García, Gonzalo
Soria-Chacartegui, Paula
Saiz-Rodríguez, Miriam
Ochoa, Dolores
Abad-Santos, Francisco
author_facet Zubiaur, Pablo
Mejía-Abril, Gina
Navares-Gómez, Marcos
Villapalos-García, Gonzalo
Soria-Chacartegui, Paula
Saiz-Rodríguez, Miriam
Ochoa, Dolores
Abad-Santos, Francisco
author_sort Zubiaur, Pablo
collection PubMed
description The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document, the genotyping results since the establishment of our Pharmacogenetics Unit in 2006 are described, as well as the historical implementation process that was carried out since then. Finally, this progress justified the constitution of La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics (PriME-PGx), promoted by the Clinical Pharmacology Department of Hospital Universitario de La Princesa (Madrid, Spain). Here, we present the initiative along with the two first ongoing projects: the PROFILE project, which promotes modernization of pharmacogenetic reporting (i.e., from classic gene-drug pair reporting to complete pharmacogenetic reporting or the creation of pharmacogenetic profiles specific to the Hospital’s departments) and the GENOTRIAL project, which promotes the communication of relevant pharmacogenetic findings to any healthy volunteer participating in any bioequivalence clinical trial at the Clinical Trials Unit of Hospital Universitario de La Princesa (UECHUP).
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spelling pubmed-84322572021-09-11 PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics Zubiaur, Pablo Mejía-Abril, Gina Navares-Gómez, Marcos Villapalos-García, Gonzalo Soria-Chacartegui, Paula Saiz-Rodríguez, Miriam Ochoa, Dolores Abad-Santos, Francisco J Clin Med Review The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document, the genotyping results since the establishment of our Pharmacogenetics Unit in 2006 are described, as well as the historical implementation process that was carried out since then. Finally, this progress justified the constitution of La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics (PriME-PGx), promoted by the Clinical Pharmacology Department of Hospital Universitario de La Princesa (Madrid, Spain). Here, we present the initiative along with the two first ongoing projects: the PROFILE project, which promotes modernization of pharmacogenetic reporting (i.e., from classic gene-drug pair reporting to complete pharmacogenetic reporting or the creation of pharmacogenetic profiles specific to the Hospital’s departments) and the GENOTRIAL project, which promotes the communication of relevant pharmacogenetic findings to any healthy volunteer participating in any bioequivalence clinical trial at the Clinical Trials Unit of Hospital Universitario de La Princesa (UECHUP). MDPI 2021-08-24 /pmc/articles/PMC8432257/ /pubmed/34501219 http://dx.doi.org/10.3390/jcm10173772 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zubiaur, Pablo
Mejía-Abril, Gina
Navares-Gómez, Marcos
Villapalos-García, Gonzalo
Soria-Chacartegui, Paula
Saiz-Rodríguez, Miriam
Ochoa, Dolores
Abad-Santos, Francisco
PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title_full PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title_fullStr PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title_full_unstemmed PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title_short PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
title_sort prime-pgx: la princesa university hospital multidisciplinary initiative for the implementation of pharmacogenetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432257/
https://www.ncbi.nlm.nih.gov/pubmed/34501219
http://dx.doi.org/10.3390/jcm10173772
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