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PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics
The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432257/ https://www.ncbi.nlm.nih.gov/pubmed/34501219 http://dx.doi.org/10.3390/jcm10173772 |
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author | Zubiaur, Pablo Mejía-Abril, Gina Navares-Gómez, Marcos Villapalos-García, Gonzalo Soria-Chacartegui, Paula Saiz-Rodríguez, Miriam Ochoa, Dolores Abad-Santos, Francisco |
author_facet | Zubiaur, Pablo Mejía-Abril, Gina Navares-Gómez, Marcos Villapalos-García, Gonzalo Soria-Chacartegui, Paula Saiz-Rodríguez, Miriam Ochoa, Dolores Abad-Santos, Francisco |
author_sort | Zubiaur, Pablo |
collection | PubMed |
description | The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document, the genotyping results since the establishment of our Pharmacogenetics Unit in 2006 are described, as well as the historical implementation process that was carried out since then. Finally, this progress justified the constitution of La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics (PriME-PGx), promoted by the Clinical Pharmacology Department of Hospital Universitario de La Princesa (Madrid, Spain). Here, we present the initiative along with the two first ongoing projects: the PROFILE project, which promotes modernization of pharmacogenetic reporting (i.e., from classic gene-drug pair reporting to complete pharmacogenetic reporting or the creation of pharmacogenetic profiles specific to the Hospital’s departments) and the GENOTRIAL project, which promotes the communication of relevant pharmacogenetic findings to any healthy volunteer participating in any bioequivalence clinical trial at the Clinical Trials Unit of Hospital Universitario de La Princesa (UECHUP). |
format | Online Article Text |
id | pubmed-8432257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84322572021-09-11 PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics Zubiaur, Pablo Mejía-Abril, Gina Navares-Gómez, Marcos Villapalos-García, Gonzalo Soria-Chacartegui, Paula Saiz-Rodríguez, Miriam Ochoa, Dolores Abad-Santos, Francisco J Clin Med Review The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document, the genotyping results since the establishment of our Pharmacogenetics Unit in 2006 are described, as well as the historical implementation process that was carried out since then. Finally, this progress justified the constitution of La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics (PriME-PGx), promoted by the Clinical Pharmacology Department of Hospital Universitario de La Princesa (Madrid, Spain). Here, we present the initiative along with the two first ongoing projects: the PROFILE project, which promotes modernization of pharmacogenetic reporting (i.e., from classic gene-drug pair reporting to complete pharmacogenetic reporting or the creation of pharmacogenetic profiles specific to the Hospital’s departments) and the GENOTRIAL project, which promotes the communication of relevant pharmacogenetic findings to any healthy volunteer participating in any bioequivalence clinical trial at the Clinical Trials Unit of Hospital Universitario de La Princesa (UECHUP). MDPI 2021-08-24 /pmc/articles/PMC8432257/ /pubmed/34501219 http://dx.doi.org/10.3390/jcm10173772 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zubiaur, Pablo Mejía-Abril, Gina Navares-Gómez, Marcos Villapalos-García, Gonzalo Soria-Chacartegui, Paula Saiz-Rodríguez, Miriam Ochoa, Dolores Abad-Santos, Francisco PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title | PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title_full | PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title_fullStr | PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title_full_unstemmed | PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title_short | PriME-PGx: La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics |
title_sort | prime-pgx: la princesa university hospital multidisciplinary initiative for the implementation of pharmacogenetics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432257/ https://www.ncbi.nlm.nih.gov/pubmed/34501219 http://dx.doi.org/10.3390/jcm10173772 |
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