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The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lun...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432449/ https://www.ncbi.nlm.nih.gov/pubmed/34501461 http://dx.doi.org/10.3390/jcm10174013 |
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author | Schneider, Matthias Schäfer, Niklas Bode, Christian Eichhorn, Lars Giordano, Frank A. Güresir, Erdem Heimann, Muriel Ko, Yon-Dschun Landsberg, Jennifer Lehmann, Felix Radbruch, Alexander Schaub, Christina Schwab, Katjana S. Weller, Johannes Herrlinger, Ulrich Vatter, Hartmut Schuss, Patrick |
author_facet | Schneider, Matthias Schäfer, Niklas Bode, Christian Eichhorn, Lars Giordano, Frank A. Güresir, Erdem Heimann, Muriel Ko, Yon-Dschun Landsberg, Jennifer Lehmann, Felix Radbruch, Alexander Schaub, Christina Schwab, Katjana S. Weller, Johannes Herrlinger, Ulrich Vatter, Hartmut Schuss, Patrick |
author_sort | Schneider, Matthias |
collection | PubMed |
description | Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lung cancer (NSCLC). Methods: A total of 154 patients with NSCLC that had been surgically treated for BM at the authors’ institution between 2013 and 2018 were included for a further analysis. A multivariate analysis was performed to identify the predictors of a poor overall survival (OS). Results: The median overall survival (mOS) was 11 months (95% CI 8.2–13.8). An age > 65 years, the infratentorial location of BM, elevated preoperative C-reactive protein levels, a perioperative red blood cell transfusion, postoperative prolonged mechanical ventilation (>48 h) and the occurrence of postoperative adverse events were identified as independent factors of a poor OS. Conclusions: The present study identified several predictors for a worsened OS in patients that underwent surgery for BM of NSCLC. These findings might guide a better risk/benefit assessment in the course of metastatic NSCLC therapy and might help to more sufficiently cope with the challenges of cancer therapy in these advanced stages of disease. |
format | Online Article Text |
id | pubmed-8432449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84324492021-09-11 The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival Schneider, Matthias Schäfer, Niklas Bode, Christian Eichhorn, Lars Giordano, Frank A. Güresir, Erdem Heimann, Muriel Ko, Yon-Dschun Landsberg, Jennifer Lehmann, Felix Radbruch, Alexander Schaub, Christina Schwab, Katjana S. Weller, Johannes Herrlinger, Ulrich Vatter, Hartmut Schuss, Patrick J Clin Med Article Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lung cancer (NSCLC). Methods: A total of 154 patients with NSCLC that had been surgically treated for BM at the authors’ institution between 2013 and 2018 were included for a further analysis. A multivariate analysis was performed to identify the predictors of a poor overall survival (OS). Results: The median overall survival (mOS) was 11 months (95% CI 8.2–13.8). An age > 65 years, the infratentorial location of BM, elevated preoperative C-reactive protein levels, a perioperative red blood cell transfusion, postoperative prolonged mechanical ventilation (>48 h) and the occurrence of postoperative adverse events were identified as independent factors of a poor OS. Conclusions: The present study identified several predictors for a worsened OS in patients that underwent surgery for BM of NSCLC. These findings might guide a better risk/benefit assessment in the course of metastatic NSCLC therapy and might help to more sufficiently cope with the challenges of cancer therapy in these advanced stages of disease. MDPI 2021-09-05 /pmc/articles/PMC8432449/ /pubmed/34501461 http://dx.doi.org/10.3390/jcm10174013 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schneider, Matthias Schäfer, Niklas Bode, Christian Eichhorn, Lars Giordano, Frank A. Güresir, Erdem Heimann, Muriel Ko, Yon-Dschun Landsberg, Jennifer Lehmann, Felix Radbruch, Alexander Schaub, Christina Schwab, Katjana S. Weller, Johannes Herrlinger, Ulrich Vatter, Hartmut Schuss, Patrick The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title | The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title_full | The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title_fullStr | The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title_full_unstemmed | The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title_short | The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival |
title_sort | surgical management of brain metastases in non-small cell lung cancer (nsclc): identification of the early laboratory and clinical determinants of survival |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432449/ https://www.ncbi.nlm.nih.gov/pubmed/34501461 http://dx.doi.org/10.3390/jcm10174013 |
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