Cargando…

The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival

Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lun...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Matthias, Schäfer, Niklas, Bode, Christian, Eichhorn, Lars, Giordano, Frank A., Güresir, Erdem, Heimann, Muriel, Ko, Yon-Dschun, Landsberg, Jennifer, Lehmann, Felix, Radbruch, Alexander, Schaub, Christina, Schwab, Katjana S., Weller, Johannes, Herrlinger, Ulrich, Vatter, Hartmut, Schuss, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432449/
https://www.ncbi.nlm.nih.gov/pubmed/34501461
http://dx.doi.org/10.3390/jcm10174013
_version_ 1783751168623640576
author Schneider, Matthias
Schäfer, Niklas
Bode, Christian
Eichhorn, Lars
Giordano, Frank A.
Güresir, Erdem
Heimann, Muriel
Ko, Yon-Dschun
Landsberg, Jennifer
Lehmann, Felix
Radbruch, Alexander
Schaub, Christina
Schwab, Katjana S.
Weller, Johannes
Herrlinger, Ulrich
Vatter, Hartmut
Schuss, Patrick
author_facet Schneider, Matthias
Schäfer, Niklas
Bode, Christian
Eichhorn, Lars
Giordano, Frank A.
Güresir, Erdem
Heimann, Muriel
Ko, Yon-Dschun
Landsberg, Jennifer
Lehmann, Felix
Radbruch, Alexander
Schaub, Christina
Schwab, Katjana S.
Weller, Johannes
Herrlinger, Ulrich
Vatter, Hartmut
Schuss, Patrick
author_sort Schneider, Matthias
collection PubMed
description Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lung cancer (NSCLC). Methods: A total of 154 patients with NSCLC that had been surgically treated for BM at the authors’ institution between 2013 and 2018 were included for a further analysis. A multivariate analysis was performed to identify the predictors of a poor overall survival (OS). Results: The median overall survival (mOS) was 11 months (95% CI 8.2–13.8). An age > 65 years, the infratentorial location of BM, elevated preoperative C-reactive protein levels, a perioperative red blood cell transfusion, postoperative prolonged mechanical ventilation (>48 h) and the occurrence of postoperative adverse events were identified as independent factors of a poor OS. Conclusions: The present study identified several predictors for a worsened OS in patients that underwent surgery for BM of NSCLC. These findings might guide a better risk/benefit assessment in the course of metastatic NSCLC therapy and might help to more sufficiently cope with the challenges of cancer therapy in these advanced stages of disease.
format Online
Article
Text
id pubmed-8432449
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84324492021-09-11 The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival Schneider, Matthias Schäfer, Niklas Bode, Christian Eichhorn, Lars Giordano, Frank A. Güresir, Erdem Heimann, Muriel Ko, Yon-Dschun Landsberg, Jennifer Lehmann, Felix Radbruch, Alexander Schaub, Christina Schwab, Katjana S. Weller, Johannes Herrlinger, Ulrich Vatter, Hartmut Schuss, Patrick J Clin Med Article Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgical treatment of BM derived from non-small cell lung cancer (NSCLC). Methods: A total of 154 patients with NSCLC that had been surgically treated for BM at the authors’ institution between 2013 and 2018 were included for a further analysis. A multivariate analysis was performed to identify the predictors of a poor overall survival (OS). Results: The median overall survival (mOS) was 11 months (95% CI 8.2–13.8). An age > 65 years, the infratentorial location of BM, elevated preoperative C-reactive protein levels, a perioperative red blood cell transfusion, postoperative prolonged mechanical ventilation (>48 h) and the occurrence of postoperative adverse events were identified as independent factors of a poor OS. Conclusions: The present study identified several predictors for a worsened OS in patients that underwent surgery for BM of NSCLC. These findings might guide a better risk/benefit assessment in the course of metastatic NSCLC therapy and might help to more sufficiently cope with the challenges of cancer therapy in these advanced stages of disease. MDPI 2021-09-05 /pmc/articles/PMC8432449/ /pubmed/34501461 http://dx.doi.org/10.3390/jcm10174013 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schneider, Matthias
Schäfer, Niklas
Bode, Christian
Eichhorn, Lars
Giordano, Frank A.
Güresir, Erdem
Heimann, Muriel
Ko, Yon-Dschun
Landsberg, Jennifer
Lehmann, Felix
Radbruch, Alexander
Schaub, Christina
Schwab, Katjana S.
Weller, Johannes
Herrlinger, Ulrich
Vatter, Hartmut
Schuss, Patrick
The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title_full The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title_fullStr The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title_full_unstemmed The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title_short The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
title_sort surgical management of brain metastases in non-small cell lung cancer (nsclc): identification of the early laboratory and clinical determinants of survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432449/
https://www.ncbi.nlm.nih.gov/pubmed/34501461
http://dx.doi.org/10.3390/jcm10174013
work_keys_str_mv AT schneidermatthias thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schaferniklas thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT bodechristian thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT eichhornlars thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT giordanofranka thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT guresirerdem thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT heimannmuriel thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT koyondschun thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT landsbergjennifer thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT lehmannfelix thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT radbruchalexander thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schaubchristina thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schwabkatjanas thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT wellerjohannes thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT herrlingerulrich thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT vatterhartmut thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schusspatrick thesurgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schneidermatthias surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schaferniklas surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT bodechristian surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT eichhornlars surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT giordanofranka surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT guresirerdem surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT heimannmuriel surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT koyondschun surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT landsbergjennifer surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT lehmannfelix surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT radbruchalexander surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schaubchristina surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schwabkatjanas surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT wellerjohannes surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT herrlingerulrich surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT vatterhartmut surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival
AT schusspatrick surgicalmanagementofbrainmetastasesinnonsmallcelllungcancernsclcidentificationoftheearlylaboratoryandclinicaldeterminantsofsurvival