Cargando…

Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study

Apparent treatment-resistant hypertension (ATRH) is closely related to chronic kidney disease (CKD); however, the long-term outcomes and the effects of improvement in ATRH in patients with CKD are not well understood. We evaluated the relationship between the persistence of ATRH and the progression...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Su-Hyun, Kim, Young-Jin, Choi, Hong-Sang, Kim, Chang-Seong, Bae, Eun-Hui, Ahn, Curie, Oh, Kook-Hwan, Park, Sue-Kyung, Lee, Kyu-Beck, Sung, Suah, Han, Seung-Hyeok, Ma, Seong-Kwon, Kim, Soo-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432533/
https://www.ncbi.nlm.nih.gov/pubmed/34501446
http://dx.doi.org/10.3390/jcm10173998
_version_ 1783751185696555008
author Song, Su-Hyun
Kim, Young-Jin
Choi, Hong-Sang
Kim, Chang-Seong
Bae, Eun-Hui
Ahn, Curie
Oh, Kook-Hwan
Park, Sue-Kyung
Lee, Kyu-Beck
Sung, Suah
Han, Seung-Hyeok
Ma, Seong-Kwon
Kim, Soo-Wan
author_facet Song, Su-Hyun
Kim, Young-Jin
Choi, Hong-Sang
Kim, Chang-Seong
Bae, Eun-Hui
Ahn, Curie
Oh, Kook-Hwan
Park, Sue-Kyung
Lee, Kyu-Beck
Sung, Suah
Han, Seung-Hyeok
Ma, Seong-Kwon
Kim, Soo-Wan
author_sort Song, Su-Hyun
collection PubMed
description Apparent treatment-resistant hypertension (ATRH) is closely related to chronic kidney disease (CKD); however, the long-term outcomes and the effects of improvement in ATRH in patients with CKD are not well understood. We evaluated the relationship between the persistence of ATRH and the progression of CKD. This cohort study enrolled 1921 patients with CKD. ATRH was defined as blood pressure above 140/90 mmHg and intake of three different types of antihypertensive agents, including diuretics, or intake of four or more different types of antihypertensive agents, regardless of blood pressure. We defined ATRH subgroups according to the ATRH status at the index year and two years later. The prevalence of ATRH at baseline was 14.0%. The presence of ATRH at both time points was an independent risk factor for end-point renal outcome (HR, 1.41; 95% CI, 1.04–1.92; p = 0.027). On the other hand, the presence of ATRH at any one of the time points was not statistically significant. In conclusion, persistent ATRH is more important for the prognosis of renal disease than the initial ATRH status. Continuous follow-up and appropriate treatment are important to improve the renal outcomes.
format Online
Article
Text
id pubmed-8432533
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84325332021-09-11 Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study Song, Su-Hyun Kim, Young-Jin Choi, Hong-Sang Kim, Chang-Seong Bae, Eun-Hui Ahn, Curie Oh, Kook-Hwan Park, Sue-Kyung Lee, Kyu-Beck Sung, Suah Han, Seung-Hyeok Ma, Seong-Kwon Kim, Soo-Wan J Clin Med Article Apparent treatment-resistant hypertension (ATRH) is closely related to chronic kidney disease (CKD); however, the long-term outcomes and the effects of improvement in ATRH in patients with CKD are not well understood. We evaluated the relationship between the persistence of ATRH and the progression of CKD. This cohort study enrolled 1921 patients with CKD. ATRH was defined as blood pressure above 140/90 mmHg and intake of three different types of antihypertensive agents, including diuretics, or intake of four or more different types of antihypertensive agents, regardless of blood pressure. We defined ATRH subgroups according to the ATRH status at the index year and two years later. The prevalence of ATRH at baseline was 14.0%. The presence of ATRH at both time points was an independent risk factor for end-point renal outcome (HR, 1.41; 95% CI, 1.04–1.92; p = 0.027). On the other hand, the presence of ATRH at any one of the time points was not statistically significant. In conclusion, persistent ATRH is more important for the prognosis of renal disease than the initial ATRH status. Continuous follow-up and appropriate treatment are important to improve the renal outcomes. MDPI 2021-09-03 /pmc/articles/PMC8432533/ /pubmed/34501446 http://dx.doi.org/10.3390/jcm10173998 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Su-Hyun
Kim, Young-Jin
Choi, Hong-Sang
Kim, Chang-Seong
Bae, Eun-Hui
Ahn, Curie
Oh, Kook-Hwan
Park, Sue-Kyung
Lee, Kyu-Beck
Sung, Suah
Han, Seung-Hyeok
Ma, Seong-Kwon
Kim, Soo-Wan
Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title_full Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title_fullStr Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title_full_unstemmed Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title_short Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study
title_sort persistent resistant hypertension has worse renal outcomes in chronic kidney disease than that resolved in two years: results from the know-ckd study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432533/
https://www.ncbi.nlm.nih.gov/pubmed/34501446
http://dx.doi.org/10.3390/jcm10173998
work_keys_str_mv AT songsuhyun persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT kimyoungjin persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT choihongsang persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT kimchangseong persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT baeeunhui persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT ahncurie persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT ohkookhwan persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT parksuekyung persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT leekyubeck persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT sungsuah persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT hanseunghyeok persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT maseongkwon persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy
AT kimsoowan persistentresistanthypertensionhasworserenaloutcomesinchronickidneydiseasethanthatresolvedintwoyearsresultsfromtheknowckdstudy