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Molecular trafficking between bacteria determines the shape of gut microbial community
Complex inter-bacterial interactions largely influence the structure and function of the gut microbial community. Though several host-associated phenomena have often been shown to be involved in the stability, structure, and function of the gut microbial community, the implication of contact-depende...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432619/ https://www.ncbi.nlm.nih.gov/pubmed/34455923 http://dx.doi.org/10.1080/19490976.2021.1959841 |
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author | Boopathi, Seenivasan Liu, Danrui Jia, Ai-Qun |
author_facet | Boopathi, Seenivasan Liu, Danrui Jia, Ai-Qun |
author_sort | Boopathi, Seenivasan |
collection | PubMed |
description | Complex inter-bacterial interactions largely influence the structure and function of the gut microbial community. Though several host-associated phenomena have often been shown to be involved in the stability, structure, and function of the gut microbial community, the implication of contact-dependent and contact-independent inter-bacterial interactions has been overlooked. Such interactions are tightly governed at multiple layers through several extracellular organelles, including contact-dependent inhibition (CDI), nanotubes, type VI secretion system (T6SS), and membrane vesicles (MVs). Recent advancements in molecular techniques have revealed that such extracellular organelles function beyond exhibiting competitive behavior and are also involved in manifesting cooperative behaviors. Cooperation between bacteria occurs through the sharing of several beneficial molecules including nucleic acids, proteins, metabolites, and nutrients among the members of the community, while competition occurs by means of multiple toxins. Intrinsic coordination between contact-dependent and contact-independent mechanisms collectively provides a fitness advantage and increased colonization resistance to the gut microbiota, where molecular trafficking plays a key role. This review is intended to provide a comprehensive view of the salient features of the different bacterial interactions and to highlight how microbiota deploy multifaceted organelles, for exerting both cooperative and competitive behaviors. We discuss the current knowledge of bacterial molecular trafficking and its impact on shaping the gut microbial community. |
format | Online Article Text |
id | pubmed-8432619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84326192021-09-11 Molecular trafficking between bacteria determines the shape of gut microbial community Boopathi, Seenivasan Liu, Danrui Jia, Ai-Qun Gut Microbes Review Complex inter-bacterial interactions largely influence the structure and function of the gut microbial community. Though several host-associated phenomena have often been shown to be involved in the stability, structure, and function of the gut microbial community, the implication of contact-dependent and contact-independent inter-bacterial interactions has been overlooked. Such interactions are tightly governed at multiple layers through several extracellular organelles, including contact-dependent inhibition (CDI), nanotubes, type VI secretion system (T6SS), and membrane vesicles (MVs). Recent advancements in molecular techniques have revealed that such extracellular organelles function beyond exhibiting competitive behavior and are also involved in manifesting cooperative behaviors. Cooperation between bacteria occurs through the sharing of several beneficial molecules including nucleic acids, proteins, metabolites, and nutrients among the members of the community, while competition occurs by means of multiple toxins. Intrinsic coordination between contact-dependent and contact-independent mechanisms collectively provides a fitness advantage and increased colonization resistance to the gut microbiota, where molecular trafficking plays a key role. This review is intended to provide a comprehensive view of the salient features of the different bacterial interactions and to highlight how microbiota deploy multifaceted organelles, for exerting both cooperative and competitive behaviors. We discuss the current knowledge of bacterial molecular trafficking and its impact on shaping the gut microbial community. Taylor & Francis 2021-08-30 /pmc/articles/PMC8432619/ /pubmed/34455923 http://dx.doi.org/10.1080/19490976.2021.1959841 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Boopathi, Seenivasan Liu, Danrui Jia, Ai-Qun Molecular trafficking between bacteria determines the shape of gut microbial community |
title | Molecular trafficking between bacteria determines the shape of gut microbial community |
title_full | Molecular trafficking between bacteria determines the shape of gut microbial community |
title_fullStr | Molecular trafficking between bacteria determines the shape of gut microbial community |
title_full_unstemmed | Molecular trafficking between bacteria determines the shape of gut microbial community |
title_short | Molecular trafficking between bacteria determines the shape of gut microbial community |
title_sort | molecular trafficking between bacteria determines the shape of gut microbial community |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432619/ https://www.ncbi.nlm.nih.gov/pubmed/34455923 http://dx.doi.org/10.1080/19490976.2021.1959841 |
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