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Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients

BACKGROUND: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients. METHODS: Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for CO...

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Detalles Bibliográficos
Autores principales: Villoteau, Adeline, Asfar, Marine, Otekpo, Marie, Loison, Jocelyne, Gautier, Jennifer, Annweiler, Cédric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432790/
https://www.ncbi.nlm.nih.gov/pubmed/34506514
http://dx.doi.org/10.1371/journal.pone.0256931
Descripción
Sumario:BACKGROUND: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients. METHODS: Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments. RESULTS: Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP<35mg/L had longer survival time than the others (log-rank P<0.001). CONCLUSIONS: Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients.