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Statins use and COVID-19 outcomes in hospitalized patients

BACKGROUND: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering agents, statins, are associated with reduced mortality in patients with various respiratory infections. We sought to i...

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Autores principales: Ayeh, Samuel K., Abbey, Enoch J., Khalifa, Banda A. A., Nudotor, Richard D., Osei, Albert Danso, Chidambaram, Vignesh, Osuji, Ngozi, Khan, Samiha, Salia, Emmanuella L., Oduwole, Modupe O., Yusuf, Hasiya E., Lasisi, Oluwatobi, Nosakhare, Esosa, Karakousis, Petros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432819/
https://www.ncbi.nlm.nih.gov/pubmed/34506533
http://dx.doi.org/10.1371/journal.pone.0256899
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author Ayeh, Samuel K.
Abbey, Enoch J.
Khalifa, Banda A. A.
Nudotor, Richard D.
Osei, Albert Danso
Chidambaram, Vignesh
Osuji, Ngozi
Khan, Samiha
Salia, Emmanuella L.
Oduwole, Modupe O.
Yusuf, Hasiya E.
Lasisi, Oluwatobi
Nosakhare, Esosa
Karakousis, Petros C.
author_facet Ayeh, Samuel K.
Abbey, Enoch J.
Khalifa, Banda A. A.
Nudotor, Richard D.
Osei, Albert Danso
Chidambaram, Vignesh
Osuji, Ngozi
Khan, Samiha
Salia, Emmanuella L.
Oduwole, Modupe O.
Yusuf, Hasiya E.
Lasisi, Oluwatobi
Nosakhare, Esosa
Karakousis, Petros C.
author_sort Ayeh, Samuel K.
collection PubMed
description BACKGROUND: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering agents, statins, are associated with reduced mortality in patients with various respiratory infections. We sought to investigate the relationship between statin use and COVID-19 disease severity in hospitalized patients. METHODS: A retrospective analysis of COVID-19 patients admitted to the Johns Hopkins Medical Institutions between March 1, 2020 and June 30, 2020 was performed. The outcomes of interest were mortality and severe COVID-19 infection, as defined by prolonged hospital stay (≥ 7 days) and/ or invasive mechanical ventilation. Logistic regression, Cox proportional hazards regression and propensity score matching were used to obtain both univariable and multivariable associations between covariates and outcomes in addition to the average treatment effect of statin use. RESULTS: Of the 4,447 patients who met our inclusion criteria, 594 (13.4%) patients were exposed to statins on admission, of which 340 (57.2%) were male. The mean age was higher in statin users compared to non-users [64.9 ± 13.4 vs. 45.5 ± 16.6 years, p <0.001]. The average treatment effect of statin use on COVID-19-related mortality was RR = 1.00 (95% CI: 0.99–1.01, p = 0.928), while its effect on severe COVID-19 infection was RR = 1.18 (95% CI: 1.11–1.27, p <0.001). CONCLUSION: Statin use was not associated with altered mortality, but with an 18% increased risk of severe COVID-19 infection.
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spelling pubmed-84328192021-09-11 Statins use and COVID-19 outcomes in hospitalized patients Ayeh, Samuel K. Abbey, Enoch J. Khalifa, Banda A. A. Nudotor, Richard D. Osei, Albert Danso Chidambaram, Vignesh Osuji, Ngozi Khan, Samiha Salia, Emmanuella L. Oduwole, Modupe O. Yusuf, Hasiya E. Lasisi, Oluwatobi Nosakhare, Esosa Karakousis, Petros C. PLoS One Research Article BACKGROUND: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering agents, statins, are associated with reduced mortality in patients with various respiratory infections. We sought to investigate the relationship between statin use and COVID-19 disease severity in hospitalized patients. METHODS: A retrospective analysis of COVID-19 patients admitted to the Johns Hopkins Medical Institutions between March 1, 2020 and June 30, 2020 was performed. The outcomes of interest were mortality and severe COVID-19 infection, as defined by prolonged hospital stay (≥ 7 days) and/ or invasive mechanical ventilation. Logistic regression, Cox proportional hazards regression and propensity score matching were used to obtain both univariable and multivariable associations between covariates and outcomes in addition to the average treatment effect of statin use. RESULTS: Of the 4,447 patients who met our inclusion criteria, 594 (13.4%) patients were exposed to statins on admission, of which 340 (57.2%) were male. The mean age was higher in statin users compared to non-users [64.9 ± 13.4 vs. 45.5 ± 16.6 years, p <0.001]. The average treatment effect of statin use on COVID-19-related mortality was RR = 1.00 (95% CI: 0.99–1.01, p = 0.928), while its effect on severe COVID-19 infection was RR = 1.18 (95% CI: 1.11–1.27, p <0.001). CONCLUSION: Statin use was not associated with altered mortality, but with an 18% increased risk of severe COVID-19 infection. Public Library of Science 2021-09-10 /pmc/articles/PMC8432819/ /pubmed/34506533 http://dx.doi.org/10.1371/journal.pone.0256899 Text en © 2021 Ayeh et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ayeh, Samuel K.
Abbey, Enoch J.
Khalifa, Banda A. A.
Nudotor, Richard D.
Osei, Albert Danso
Chidambaram, Vignesh
Osuji, Ngozi
Khan, Samiha
Salia, Emmanuella L.
Oduwole, Modupe O.
Yusuf, Hasiya E.
Lasisi, Oluwatobi
Nosakhare, Esosa
Karakousis, Petros C.
Statins use and COVID-19 outcomes in hospitalized patients
title Statins use and COVID-19 outcomes in hospitalized patients
title_full Statins use and COVID-19 outcomes in hospitalized patients
title_fullStr Statins use and COVID-19 outcomes in hospitalized patients
title_full_unstemmed Statins use and COVID-19 outcomes in hospitalized patients
title_short Statins use and COVID-19 outcomes in hospitalized patients
title_sort statins use and covid-19 outcomes in hospitalized patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432819/
https://www.ncbi.nlm.nih.gov/pubmed/34506533
http://dx.doi.org/10.1371/journal.pone.0256899
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