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Mn(2+) coordinates Cap-0-RNA to align substrates for efficient 2′-O-methyl transfer by SARS-CoV-2 nsp16

Capping of viral messenger RNAs is essential for efficient translation, for virus replication, and for preventing detection by the host cell innate response system. The SARS-CoV-2 genome encodes the 2′-O-methyltransferase nsp16, which, when bound to the coactivator nsp10, uses S-adenosylmethionine (...

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Detalles Bibliográficos
Autores principales:	Minasov, George, Rosas-Lemus, Monica, Shuvalova, Ludmilla, Inniss, Nicole L., Brunzelle, Joseph S., Daczkowski, Courtney M., Hoover, Paul, Mesecar, Andrew D., Satchell, Karla J. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432954/ https://www.ncbi.nlm.nih.gov/pubmed/34131072 http://dx.doi.org/10.1126/scisignal.abh2071

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