Cargando…

Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination that is effective for all tumor types. To address...

Descripción completa

Detalles Bibliográficos
Autores principales:	Christie, John D., Appel, Nicole, Canter, Hannah, Achi, Jazmin Galvan, Elliott, Natalie M., de Matos, Ana Lemos, Franco, Lina, Kilbourne, Jacquelyn, Lowe, Kenneth, Rahman, Masmudur M., Villa, Nancy Y., Carmen, Joshua, Luna, Evelyn, Blattman, Joseph, McFadden, Grant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433070/ https://www.ncbi.nlm.nih.gov/pubmed/34553039 http://dx.doi.org/10.1016/j.omto.2021.07.014

Ejemplares similares

Systemic Delivery of mLIGHT-Armed Myxoma Virus Is Therapeutic for Later-Stage Syngeneic Murine Lung Metastatic Osteosarcoma
por: Christie, John D., et al.
Publicado: (2022)

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma
por: Villa, Nancy.Y., et al.
Publicado: (2020)

Oncolytic Virotherapy with Myxoma Virus
por: Rahman, Masmudur M., et al.
Publicado: (2020)

Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma
por: Villa, Nancy Y., et al.
Publicado: (2022)

Nuclear Export Inhibitor Selinexor Enhances Oncolytic Myxoma Virus Therapy against Cancer
por: Rahman, Masmudur M., et al.
Publicado: (2023)

Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways
por: Rahman, Masmudur M., et al.
Publicado: (2020)

Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN-Induced Antiviral State in a Highly Species-Specific Fashion
por: Rahman, Masmudur M., et al.
Publicado: (2017)

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor
por: Lilly, Cameron L., et al.
Publicado: (2016)

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells
por: Rahman, Masmudur M., et al.
Publicado: (2017)

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma
por: Jazowiecka-Rakus, Joanna, et al.
Publicado: (2020)

Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013
por: Rahman, Masmudur M., et al.
Publicado: (2009)

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication
por: Rahman, Masmudur M., et al.
Publicado: (2013)

NSCs are permissive to oncolytic Myxoma virus and provide a delivery method for targeted ovarian cancer therapy
por: Cornejo, Yvonne, et al.
Publicado: (2020)

Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma
por: Jazowiecka-Rakus, Joanna, et al.
Publicado: (2022)

The Oncolytic Activity of Myxoma Virus against Soft Tissue Sarcoma Is Mediated by the Overexpression of Ribonucleotide Reductase
por: Woo, Yanghee, et al.
Publicado: (2021)

RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells
por: Rahman, Masmudur M., et al.
Publicado: (2021)

Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (Lepus granatensis)
por: Águeda-Pinto, Ana, et al.
Publicado: (2019)

Myxoma Virus Targets Primary Human Leukemic Stem and Progenitor Cells While Sparing Normal Hematopoietic Stem and Progenitor Cells
por: Kim, Manbok, et al.
Publicado: (2009)

Myxoma Virus Expressing LIGHT (TNFSF14) Pre-Loaded into Adipose-Derived Mesenchymal Stem Cells Is Effective Treatment for Murine Pancreatic Adenocarcinoma
por: Jazowiecka-Rakus, Joanna, et al.
Publicado: (2021)

Modulation of Tumor Necrosis Factor by Microbial Pathogens
por: Rahman, Masmudur M, et al.
Publicado: (2006)

Modulation of NF-κB signalling by microbial pathogens
por: Rahman, Masmudur M., et al.
Publicado: (2011)

Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy
por: Rahman, Masmudur M., et al.
Publicado: (2021)

Role of cytokines in poxvirus host tropism and adaptation
por: Rahman, Masmudur M, et al.
Publicado: (2022)

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo
por: Ogbomo, Henry, et al.
Publicado: (2013)

Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic Strategies
por: Villa, Nancy Y., et al.
Publicado: (2016)

RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages
por: Wang, Fuan, et al.
Publicado: (2008)

Comparative analyses of small molecule and antibody inhibition on glycoprotein‐mediated entry of Měnglà virus with other filoviruses
por: Cooper, Laura, et al.
Publicado: (2022)

The current status and future directions of myxoma virus, a master in immune evasion
por: Spiesschaert, Bart, et al.
Publicado: (2011)

Recombinant Myxoma Virus-Derived Immune Modulator M-T7 Accelerates Cutaneous Wound Healing and Improves Tissue Remodeling
por: Yaron, Jordan R., et al.
Publicado: (2020)

Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares
por: Águeda-Pinto, Ana, et al.
Publicado: (2022)

Cytokine determinants of viral tropism
por: McFadden, Grant, et al.
Publicado: (2009)

The α2,3-Sialyltransferase Encoded by Myxoma Virus Is a Virulence Factor that Contributes to Immunosuppression
por: Boutard, Bérengère, et al.
Publicado: (2015)

Oncolytic Viruses and the Immune System: The Dynamic Duo
por: Lemos de Matos, Ana, et al.
Publicado: (2020)

TNF blockade enhances the efficacy of myxoma virus-based oncolytic virotherapy
por: Valenzuela-Cardenas, Miriam, et al.
Publicado: (2022)

Virotherapy Using Myxoma Virus Prevents Lethal Graft-versus-Host Disease following Xeno-Transplantation with Primary Human Hematopoietic Stem Cells
por: Bartee, Eric, et al.
Publicado: (2012)

Oncolytic Virotherapy for Hematological Malignancies
por: Bais, Swarna, et al.
Publicado: (2012)

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals
por: Lemos de Matos, Ana, et al.
Publicado: (2013)

Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares
por: Águeda-Pinto, Ana, et al.
Publicado: (2020)

SARS-CoV-2 cell entry and targeted antiviral development
por: Chen, Zinuo, et al.
Publicado: (2021)

M11l: A Novel Mitochondria-Localized Protein of Myxoma Virus That Blocks Apoptosis of Infected Leukocytes
por: Everett, Helen, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_fi2kf0hpifdd8k7nllc44sjlh7