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Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface

INTRODUCTION: The reported effects of SARS-CoV-2 on pregnancy outcomes are conflicting; studies frequently overlook the placenta, which is critical for the health of the mother and infant(s). This study aimed to determine the effect of pandemic stress ± SARS CoV-2 infection on placental histopatholo...

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Autores principales: Brien, Marie-Eve, Bouron-Dal Soglio, Dorothée, Dal Soglio, Solenn, Couture, Camille, Boucoiran, Isabelle, Nasr, Youssef, Widdows, Kate, Sharps, Megan C., El Demellawy, Dina, EP Heazell, Alexander, Menzies, Didier, Girard, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433096/
https://www.ncbi.nlm.nih.gov/pubmed/34537470
http://dx.doi.org/10.1016/j.placenta.2021.09.007
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author Brien, Marie-Eve
Bouron-Dal Soglio, Dorothée
Dal Soglio, Solenn
Couture, Camille
Boucoiran, Isabelle
Nasr, Youssef
Widdows, Kate
Sharps, Megan C.
El Demellawy, Dina
EP Heazell, Alexander
Menzies, Didier
Girard, Sylvie
author_facet Brien, Marie-Eve
Bouron-Dal Soglio, Dorothée
Dal Soglio, Solenn
Couture, Camille
Boucoiran, Isabelle
Nasr, Youssef
Widdows, Kate
Sharps, Megan C.
El Demellawy, Dina
EP Heazell, Alexander
Menzies, Didier
Girard, Sylvie
author_sort Brien, Marie-Eve
collection PubMed
description INTRODUCTION: The reported effects of SARS-CoV-2 on pregnancy outcomes are conflicting; studies frequently overlook the placenta, which is critical for the health of the mother and infant(s). This study aimed to determine the effect of pandemic stress ± SARS CoV-2 infection on placental histopathology. METHODS: Women were recruited in Canada (n = 69); France (n = 21) or in the UK (n = 25), between March and October 2020. Historic controls (N = 20) were also included. Placenta and fetal membrane samples were collected rapidly after delivery and were fixed and stained for histopathological analysis. Maternal demographical data and obstetric outcomes were recorded. RESULTS: Over 80% of the placentas from SARS-CoV-2+ pregnancies had histopathological abnormalities: predominantly structural (71–86%) or inflammatory (9–22%), depending on geographical location. Excessive fibrin was seen in all sites, whereas deciduitis (Canada), calcifications (UK), agglutinations and chorangiosis (France) predominated in different locations. The frequency of abnormalities was significantly higher than in SARS-CoV-2 negative women (50%, p < 0.05). Demographic and obstetric data were similar in the SARS-CoV-2+ women across all sites - characterised by predominantly Black/Middle Eastern women, and women with elevated body mass index. DISCUSSION: Overall, the frequency of placental abnormalities is increased in SARS-CoV-2+ women, but the incidence of placental abnormalities is also higher in SARS-CoV-2- women that gave birth during the pandemic, which highlights the importance of appropriate control groups to ascertain the roles of pandemic stress and SARS-CoV-2 infection on the placenta and pregnancy outcomes.
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spelling pubmed-84330962021-09-13 Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface Brien, Marie-Eve Bouron-Dal Soglio, Dorothée Dal Soglio, Solenn Couture, Camille Boucoiran, Isabelle Nasr, Youssef Widdows, Kate Sharps, Megan C. El Demellawy, Dina EP Heazell, Alexander Menzies, Didier Girard, Sylvie Placenta Article INTRODUCTION: The reported effects of SARS-CoV-2 on pregnancy outcomes are conflicting; studies frequently overlook the placenta, which is critical for the health of the mother and infant(s). This study aimed to determine the effect of pandemic stress ± SARS CoV-2 infection on placental histopathology. METHODS: Women were recruited in Canada (n = 69); France (n = 21) or in the UK (n = 25), between March and October 2020. Historic controls (N = 20) were also included. Placenta and fetal membrane samples were collected rapidly after delivery and were fixed and stained for histopathological analysis. Maternal demographical data and obstetric outcomes were recorded. RESULTS: Over 80% of the placentas from SARS-CoV-2+ pregnancies had histopathological abnormalities: predominantly structural (71–86%) or inflammatory (9–22%), depending on geographical location. Excessive fibrin was seen in all sites, whereas deciduitis (Canada), calcifications (UK), agglutinations and chorangiosis (France) predominated in different locations. The frequency of abnormalities was significantly higher than in SARS-CoV-2 negative women (50%, p < 0.05). Demographic and obstetric data were similar in the SARS-CoV-2+ women across all sites - characterised by predominantly Black/Middle Eastern women, and women with elevated body mass index. DISCUSSION: Overall, the frequency of placental abnormalities is increased in SARS-CoV-2+ women, but the incidence of placental abnormalities is also higher in SARS-CoV-2- women that gave birth during the pandemic, which highlights the importance of appropriate control groups to ascertain the roles of pandemic stress and SARS-CoV-2 infection on the placenta and pregnancy outcomes. The Author(s). Published by Elsevier Ltd. 2021-11 2021-09-11 /pmc/articles/PMC8433096/ /pubmed/34537470 http://dx.doi.org/10.1016/j.placenta.2021.09.007 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Brien, Marie-Eve
Bouron-Dal Soglio, Dorothée
Dal Soglio, Solenn
Couture, Camille
Boucoiran, Isabelle
Nasr, Youssef
Widdows, Kate
Sharps, Megan C.
El Demellawy, Dina
EP Heazell, Alexander
Menzies, Didier
Girard, Sylvie
Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title_full Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title_fullStr Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title_full_unstemmed Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title_short Pandemic stress and SARS-CoV-2 infection are associated with pathological changes at the maternal-fetal interface
title_sort pandemic stress and sars-cov-2 infection are associated with pathological changes at the maternal-fetal interface
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433096/
https://www.ncbi.nlm.nih.gov/pubmed/34537470
http://dx.doi.org/10.1016/j.placenta.2021.09.007
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