Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities

Long-term care facilities (LTCFs) bear disproportionate burden of COVID-19 and are prioritized for vaccine deployment. LTCF outbreaks could continue occurring during vaccine rollout due to incomplete population coverage, and the effect of vaccines on viral transmission are currently unknown. Declini...

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Autores principales: Love, Jay, Keegan, Lindsay T., Angulo, Frederick J., McLaughlin, John M., Shea, Kimberly M., Swerdlow, David L., Samore, Matthew H., Toth, Damon J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433303/
https://www.ncbi.nlm.nih.gov/pubmed/34508133
http://dx.doi.org/10.1038/s41598-021-97612-w
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author Love, Jay
Keegan, Lindsay T.
Angulo, Frederick J.
McLaughlin, John M.
Shea, Kimberly M.
Swerdlow, David L.
Samore, Matthew H.
Toth, Damon J. A.
author_facet Love, Jay
Keegan, Lindsay T.
Angulo, Frederick J.
McLaughlin, John M.
Shea, Kimberly M.
Swerdlow, David L.
Samore, Matthew H.
Toth, Damon J. A.
author_sort Love, Jay
collection PubMed
description Long-term care facilities (LTCFs) bear disproportionate burden of COVID-19 and are prioritized for vaccine deployment. LTCF outbreaks could continue occurring during vaccine rollout due to incomplete population coverage, and the effect of vaccines on viral transmission are currently unknown. Declining adherence to non-pharmaceutical interventions (NPIs) against within-facility transmission could therefore limit the effectiveness of vaccination. We built a stochastic model to simulate outbreaks in LTCF populations with differing vaccination coverage and NPI adherence to evaluate their interacting effects. Vaccination combined with strong NPI adherence produced the least morbidity and mortality. Healthcare worker vaccination improved outcomes in unvaccinated LTCF residents but was less impactful with declining NPI adherence. To prevent further illness and deaths, there is a continued need for NPIs in LTCFs during vaccine rollout.
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spelling pubmed-84333032021-09-13 Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities Love, Jay Keegan, Lindsay T. Angulo, Frederick J. McLaughlin, John M. Shea, Kimberly M. Swerdlow, David L. Samore, Matthew H. Toth, Damon J. A. Sci Rep Article Long-term care facilities (LTCFs) bear disproportionate burden of COVID-19 and are prioritized for vaccine deployment. LTCF outbreaks could continue occurring during vaccine rollout due to incomplete population coverage, and the effect of vaccines on viral transmission are currently unknown. Declining adherence to non-pharmaceutical interventions (NPIs) against within-facility transmission could therefore limit the effectiveness of vaccination. We built a stochastic model to simulate outbreaks in LTCF populations with differing vaccination coverage and NPI adherence to evaluate their interacting effects. Vaccination combined with strong NPI adherence produced the least morbidity and mortality. Healthcare worker vaccination improved outcomes in unvaccinated LTCF residents but was less impactful with declining NPI adherence. To prevent further illness and deaths, there is a continued need for NPIs in LTCFs during vaccine rollout. Nature Publishing Group UK 2021-09-10 /pmc/articles/PMC8433303/ /pubmed/34508133 http://dx.doi.org/10.1038/s41598-021-97612-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Love, Jay
Keegan, Lindsay T.
Angulo, Frederick J.
McLaughlin, John M.
Shea, Kimberly M.
Swerdlow, David L.
Samore, Matthew H.
Toth, Damon J. A.
Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title_full Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title_fullStr Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title_full_unstemmed Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title_short Continued need for non-pharmaceutical interventions after COVID-19 vaccination in long-term-care facilities
title_sort continued need for non-pharmaceutical interventions after covid-19 vaccination in long-term-care facilities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433303/
https://www.ncbi.nlm.nih.gov/pubmed/34508133
http://dx.doi.org/10.1038/s41598-021-97612-w
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