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Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery
The incidence rate of diabetes has been increasing every year in nearly all nations and regions. The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections. While microneedle arrays (MAs) have emerged as painless...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433361/ https://www.ncbi.nlm.nih.gov/pubmed/34567719 http://dx.doi.org/10.1038/s41378-020-00224-z |
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author | Yang, Jingbo Li, Yanjun Ye, Rui Zheng, Ying Li, Xiangling Chen, Yuzhen Xie, Xi Jiang, Lelun |
author_facet | Yang, Jingbo Li, Yanjun Ye, Rui Zheng, Ying Li, Xiangling Chen, Yuzhen Xie, Xi Jiang, Lelun |
author_sort | Yang, Jingbo |
collection | PubMed |
description | The incidence rate of diabetes has been increasing every year in nearly all nations and regions. The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections. While microneedle arrays (MAs) have emerged as painless delivery techniques, the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized. In this study, we developed an iontophoresis-microneedle array patch (IMAP) powered by a portable smartphone for the active and controllable transdermal delivery of insulin. The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch, achieving a one-step drug administration strategy of “penetration, diffusion and iontophoresis”. The MA of the IMAP is first pressed on the skin to create microholes and then is retracted, followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner. This method has synergistically and remarkably enhanced controlled insulin delivery. The amount of insulin can be effectively regulated by the IMAP by applying different current intensities. This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model, with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis. The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care. |
format | Online Article Text |
id | pubmed-8433361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84333612021-09-24 Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery Yang, Jingbo Li, Yanjun Ye, Rui Zheng, Ying Li, Xiangling Chen, Yuzhen Xie, Xi Jiang, Lelun Microsyst Nanoeng Article The incidence rate of diabetes has been increasing every year in nearly all nations and regions. The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections. While microneedle arrays (MAs) have emerged as painless delivery techniques, the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized. In this study, we developed an iontophoresis-microneedle array patch (IMAP) powered by a portable smartphone for the active and controllable transdermal delivery of insulin. The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch, achieving a one-step drug administration strategy of “penetration, diffusion and iontophoresis”. The MA of the IMAP is first pressed on the skin to create microholes and then is retracted, followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner. This method has synergistically and remarkably enhanced controlled insulin delivery. The amount of insulin can be effectively regulated by the IMAP by applying different current intensities. This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model, with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis. The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care. Nature Publishing Group UK 2020-12-28 /pmc/articles/PMC8433361/ /pubmed/34567719 http://dx.doi.org/10.1038/s41378-020-00224-z Text en © The Author(s) 2020, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Jingbo Li, Yanjun Ye, Rui Zheng, Ying Li, Xiangling Chen, Yuzhen Xie, Xi Jiang, Lelun Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title_full | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title_fullStr | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title_full_unstemmed | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title_short | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
title_sort | smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433361/ https://www.ncbi.nlm.nih.gov/pubmed/34567719 http://dx.doi.org/10.1038/s41378-020-00224-z |
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