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Microfluidics in cardiovascular disease research: state of the art and future outlook

Due to extremely severe morbidity and mortality worldwide, it is worth achieving a more in-depth and comprehensive understanding of cardiovascular diseases. Tremendous effort has been made to replicate the cardiovascular system and investigate the pathogenesis, diagnosis and treatment of cardiovascu...

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Autores principales: Ma, Qingming, Ma, Haixia, Xu, Fenglan, Wang, Xinyu, Sun, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433381/
https://www.ncbi.nlm.nih.gov/pubmed/34567733
http://dx.doi.org/10.1038/s41378-021-00245-2
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author Ma, Qingming
Ma, Haixia
Xu, Fenglan
Wang, Xinyu
Sun, Wentao
author_facet Ma, Qingming
Ma, Haixia
Xu, Fenglan
Wang, Xinyu
Sun, Wentao
author_sort Ma, Qingming
collection PubMed
description Due to extremely severe morbidity and mortality worldwide, it is worth achieving a more in-depth and comprehensive understanding of cardiovascular diseases. Tremendous effort has been made to replicate the cardiovascular system and investigate the pathogenesis, diagnosis and treatment of cardiovascular diseases. Microfluidics can be used as a versatile primary strategy to achieve a holistic picture of cardiovascular disease. Here, a brief review of the application of microfluidics in comprehensive cardiovascular disease research is presented, with specific discussions of the characteristics of microfluidics for investigating cardiovascular diseases integrally, including the study of pathogenetic mechanisms, the development of accurate diagnostic methods and the establishment of therapeutic treatments. Investigations of critical pathogenetic mechanisms for typical cardiovascular diseases by microfluidic-based organ-on-a-chip are categorized and reviewed, followed by a detailed summary of microfluidic-based accurate diagnostic methods. Microfluidic-assisted cardiovascular drug evaluation and screening as well as the fabrication of novel delivery vehicles are also reviewed. Finally, the challenges with and outlook on further advancing the use of microfluidics technology in cardiovascular disease research are highlighted and discussed.
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spelling pubmed-84333812021-09-24 Microfluidics in cardiovascular disease research: state of the art and future outlook Ma, Qingming Ma, Haixia Xu, Fenglan Wang, Xinyu Sun, Wentao Microsyst Nanoeng Review Article Due to extremely severe morbidity and mortality worldwide, it is worth achieving a more in-depth and comprehensive understanding of cardiovascular diseases. Tremendous effort has been made to replicate the cardiovascular system and investigate the pathogenesis, diagnosis and treatment of cardiovascular diseases. Microfluidics can be used as a versatile primary strategy to achieve a holistic picture of cardiovascular disease. Here, a brief review of the application of microfluidics in comprehensive cardiovascular disease research is presented, with specific discussions of the characteristics of microfluidics for investigating cardiovascular diseases integrally, including the study of pathogenetic mechanisms, the development of accurate diagnostic methods and the establishment of therapeutic treatments. Investigations of critical pathogenetic mechanisms for typical cardiovascular diseases by microfluidic-based organ-on-a-chip are categorized and reviewed, followed by a detailed summary of microfluidic-based accurate diagnostic methods. Microfluidic-assisted cardiovascular drug evaluation and screening as well as the fabrication of novel delivery vehicles are also reviewed. Finally, the challenges with and outlook on further advancing the use of microfluidics technology in cardiovascular disease research are highlighted and discussed. Nature Publishing Group UK 2021-03-03 /pmc/articles/PMC8433381/ /pubmed/34567733 http://dx.doi.org/10.1038/s41378-021-00245-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Ma, Qingming
Ma, Haixia
Xu, Fenglan
Wang, Xinyu
Sun, Wentao
Microfluidics in cardiovascular disease research: state of the art and future outlook
title Microfluidics in cardiovascular disease research: state of the art and future outlook
title_full Microfluidics in cardiovascular disease research: state of the art and future outlook
title_fullStr Microfluidics in cardiovascular disease research: state of the art and future outlook
title_full_unstemmed Microfluidics in cardiovascular disease research: state of the art and future outlook
title_short Microfluidics in cardiovascular disease research: state of the art and future outlook
title_sort microfluidics in cardiovascular disease research: state of the art and future outlook
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433381/
https://www.ncbi.nlm.nih.gov/pubmed/34567733
http://dx.doi.org/10.1038/s41378-021-00245-2
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