Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer

Although inhibitors targeting CDK4/6 kinases (CDK4/6i) have shown promising clinical prospect in treating ER+/HER2- breast cancers, acquired drug resistance is frequently observed and mechanistic knowledge is needed to harness their full clinical potential. Here, we report that inhibition of CDK4/6...

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Detalles Bibliográficos
Autores principales: Dang, Fabin, Nie, Li, Zhou, Jin, Shimizu, Kouhei, Chu, Chen, Wu, Zhong, Fassl, Anne, Ke, Shizhong, Wang, Yuangao, Zhang, Jinfang, Zhang, Tao, Tu, Zhenbo, Inuzuka, Hiroyuki, Sicinski, Piotr, Bass, Adam J., Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433397/
https://www.ncbi.nlm.nih.gov/pubmed/34508104
http://dx.doi.org/10.1038/s41467-021-25700-6

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