Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer

Conditional overexpression of histone reader Tripartite motif containing protein 24 (TRIM24) in mouse mammary epithelia (Trim24(COE)) drives spontaneous development of mammary carcinosarcoma tumors, lacking ER, PR and HER2. Human carcinosarcomas or metaplastic breast cancers (MpBC) are a rare, chemo...

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Detalles Bibliográficos
Autores principales: Shah, Vrutant V., Duncan, Aundrietta D., Jiang, Shiming, Stratton, Sabrina A., Allton, Kendra L., Yam, Clinton, Jain, Abhinav, Krause, Patrick M., Lu, Yue, Cai, Shirong, Tu, Yizheng, Zhou, Xinhui, Zhang, Xiaomei, Jiang, Yan, Carroll, Christopher L., Kang, Zhijun, Liu, Bin, Shen, Jianjun, Gagea, Mihai, Manu, Sebastian M., Huo, Lei, Gilcrease, Michael, Powell, Reid T., Guo, Lei, Stephan, Clifford, Davies, Peter J., Parker-Thornburg, Jan, Lozano, Guillermina, Behringer, Richard R., Piwnica-Worms, Helen, Chang, Jeffrey T., Moulder, Stacy L., Barton, Michelle Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433435/
https://www.ncbi.nlm.nih.gov/pubmed/34508101
http://dx.doi.org/10.1038/s41467-021-25650-z

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