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Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling

In human neurodegenerative diseases, neurons can transfer toxic protein aggregates to surrounding cells, promoting pathology via poorly understood mechanisms. In Caenorhabditis elegans, proteostressed neurons can expel neurotoxic proteins in large, membrane-bound vesicles called exophers. We investi...

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Detalles Bibliográficos
Autores principales:	Cooper, Jason F., Guasp, Ryan J., Arnold, Meghan Lee, Grant, Barth D., Driscoll, Monica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433523/ https://www.ncbi.nlm.nih.gov/pubmed/34475208 http://dx.doi.org/10.1073/pnas.2101410118

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