Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma

Neuroblastomas are childhood tumors with frequent fatal relapses after induction treatment, which is related to tumor evolution with additional genomic events. Our whole-genome sequencing data analysis revealed a high frequency of somatic cytosine > adenine (C > A) substitutions in primary neu...

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Detalles Bibliográficos
Autores principales: van den Boogaard, Marlinde L., Oka, Rurika, Hakkert, Anne, Schild, Linda, Ebus, Marli E., van Gerven, Michael R., Zwijnenburg, Danny A., Molenaar, Piet, Hoyng, Lieke L., Dolman, M. Emmy M., Essing, Anke H. W., Koopmans, Bianca, Helleday, Thomas, Drost, Jarno, van Boxtel, Ruben, Versteeg, Rogier, Koster, Jan, Molenaar, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433536/
https://www.ncbi.nlm.nih.gov/pubmed/34479993
http://dx.doi.org/10.1073/pnas.2007898118

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