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Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid

The novel use of ionic liquid as a solvent for biodegradable and natural organic biomaterials has increasingly sparked interest in the biomedical field. As compared to more volatile traditional solvents that rapidly degrade the protein molecular weight, the capability of polysaccharides and proteins...

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Autores principales: Rivera-Galletti, Ashley, Gough, Christopher R., Kaleem, Farhan, Burch, Michael, Ratcliffe, Chris, Lu, Ping, Salas-de la Cruz, David, Hu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433620/
https://www.ncbi.nlm.nih.gov/pubmed/34502951
http://dx.doi.org/10.3390/polym13172911
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author Rivera-Galletti, Ashley
Gough, Christopher R.
Kaleem, Farhan
Burch, Michael
Ratcliffe, Chris
Lu, Ping
Salas-de la Cruz, David
Hu, Xiao
author_facet Rivera-Galletti, Ashley
Gough, Christopher R.
Kaleem, Farhan
Burch, Michael
Ratcliffe, Chris
Lu, Ping
Salas-de la Cruz, David
Hu, Xiao
author_sort Rivera-Galletti, Ashley
collection PubMed
description The novel use of ionic liquid as a solvent for biodegradable and natural organic biomaterials has increasingly sparked interest in the biomedical field. As compared to more volatile traditional solvents that rapidly degrade the protein molecular weight, the capability of polysaccharides and proteins to dissolve seamlessly in ionic liquid and form fine and tunable biomaterials after regeneration is the key interest of this study. Here, a blended system consisting of Bombyx Mori silk fibroin protein and a cellulose derivative, cellulose acetate (CA), in the ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIMAc) was regenerated and underwent characterization to understand the structure and physical properties of the films. The change in the morphology of the biocomposites (by scanning electron microscope, SEM) and their secondary structure analysis (by Fourier-transform infrared spectroscopy, FTIR) showed that the samples underwent a wavering conformational change on a microscopic level, resulting in strong interactions and changes in their crystalline structures such as the CA crystalline and silk beta-pleated sheets once the different ratios were applied. Differential scanning calorimetry (DSC) results demonstrated that strong molecular interactions were generated between CA and silk chains, providing the blended films lower glass transitions than those of the pure silk or cellulose acetate. All films that were blended had higher thermal stability than the pure cellulose acetate sample but presented gradual changes amongst the changing of ratios, as demonstrated by thermogravimetric analysis (TGA). This study provides the basis for the comprehension of the protein-polysaccharide composites for various biomedical applications.
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spelling pubmed-84336202021-09-12 Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid Rivera-Galletti, Ashley Gough, Christopher R. Kaleem, Farhan Burch, Michael Ratcliffe, Chris Lu, Ping Salas-de la Cruz, David Hu, Xiao Polymers (Basel) Article The novel use of ionic liquid as a solvent for biodegradable and natural organic biomaterials has increasingly sparked interest in the biomedical field. As compared to more volatile traditional solvents that rapidly degrade the protein molecular weight, the capability of polysaccharides and proteins to dissolve seamlessly in ionic liquid and form fine and tunable biomaterials after regeneration is the key interest of this study. Here, a blended system consisting of Bombyx Mori silk fibroin protein and a cellulose derivative, cellulose acetate (CA), in the ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIMAc) was regenerated and underwent characterization to understand the structure and physical properties of the films. The change in the morphology of the biocomposites (by scanning electron microscope, SEM) and their secondary structure analysis (by Fourier-transform infrared spectroscopy, FTIR) showed that the samples underwent a wavering conformational change on a microscopic level, resulting in strong interactions and changes in their crystalline structures such as the CA crystalline and silk beta-pleated sheets once the different ratios were applied. Differential scanning calorimetry (DSC) results demonstrated that strong molecular interactions were generated between CA and silk chains, providing the blended films lower glass transitions than those of the pure silk or cellulose acetate. All films that were blended had higher thermal stability than the pure cellulose acetate sample but presented gradual changes amongst the changing of ratios, as demonstrated by thermogravimetric analysis (TGA). This study provides the basis for the comprehension of the protein-polysaccharide composites for various biomedical applications. MDPI 2021-08-29 /pmc/articles/PMC8433620/ /pubmed/34502951 http://dx.doi.org/10.3390/polym13172911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rivera-Galletti, Ashley
Gough, Christopher R.
Kaleem, Farhan
Burch, Michael
Ratcliffe, Chris
Lu, Ping
Salas-de la Cruz, David
Hu, Xiao
Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title_full Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title_fullStr Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title_full_unstemmed Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title_short Silk-Cellulose Acetate Biocomposite Materials Regenerated from Ionic Liquid
title_sort silk-cellulose acetate biocomposite materials regenerated from ionic liquid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433620/
https://www.ncbi.nlm.nih.gov/pubmed/34502951
http://dx.doi.org/10.3390/polym13172911
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