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Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode

In this work, a new sensitive voltammetric method for the determination of rifampicin without time-consuming preconcentration is presented. The objective was to develop a simple, fast and sensitive voltammetric procedure for the analysis of rifampicin in pharmaceutical products. The cyclic renewable...

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Detalles Bibliográficos
Autores principales: Szlósarczyk, Marek, Piech, Robert, Milc, Anna, Hubicka, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433623/
https://www.ncbi.nlm.nih.gov/pubmed/34502683
http://dx.doi.org/10.3390/s21175792
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author Szlósarczyk, Marek
Piech, Robert
Milc, Anna
Hubicka, Urszula
author_facet Szlósarczyk, Marek
Piech, Robert
Milc, Anna
Hubicka, Urszula
author_sort Szlósarczyk, Marek
collection PubMed
description In this work, a new sensitive voltammetric method for the determination of rifampicin without time-consuming preconcentration is presented. The objective was to develop a simple, fast and sensitive voltammetric procedure for the analysis of rifampicin in pharmaceutical products. The cyclic renewable mercury film silver-based electrode (Hg(Ag)FE) was applied as a working electrode for this purpose. The optimal conditions for the determination of rifampicin were defined, in terms of the composition of supporting electrolyte (including pH) and instrumental parameters (potential and time of deposition, step potential, pulse height). The method was validated resulting in a satisfactory linearity range of 0.4–250.0 µgmL(−1); the limits of detection and quantification are 0.12 µgmL(−1) and 0.4 µgmL(−1), respectively; and the repeatability of the method expressed as RSD is 4.1% (n = 6) with a surface area of 10.9 mm(2). The proposed method was successfully applied in the analysis of rifampicin in simple and composed pharmaceutical formulations.
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spelling pubmed-84336232021-09-12 Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode Szlósarczyk, Marek Piech, Robert Milc, Anna Hubicka, Urszula Sensors (Basel) Article In this work, a new sensitive voltammetric method for the determination of rifampicin without time-consuming preconcentration is presented. The objective was to develop a simple, fast and sensitive voltammetric procedure for the analysis of rifampicin in pharmaceutical products. The cyclic renewable mercury film silver-based electrode (Hg(Ag)FE) was applied as a working electrode for this purpose. The optimal conditions for the determination of rifampicin were defined, in terms of the composition of supporting electrolyte (including pH) and instrumental parameters (potential and time of deposition, step potential, pulse height). The method was validated resulting in a satisfactory linearity range of 0.4–250.0 µgmL(−1); the limits of detection and quantification are 0.12 µgmL(−1) and 0.4 µgmL(−1), respectively; and the repeatability of the method expressed as RSD is 4.1% (n = 6) with a surface area of 10.9 mm(2). The proposed method was successfully applied in the analysis of rifampicin in simple and composed pharmaceutical formulations. MDPI 2021-08-28 /pmc/articles/PMC8433623/ /pubmed/34502683 http://dx.doi.org/10.3390/s21175792 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szlósarczyk, Marek
Piech, Robert
Milc, Anna
Hubicka, Urszula
Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title_full Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title_fullStr Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title_full_unstemmed Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title_short Fast and Sensitive Voltammetric Method for the Determination of Rifampicin on Renewable Amalgam Film Electrode
title_sort fast and sensitive voltammetric method for the determination of rifampicin on renewable amalgam film electrode
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433623/
https://www.ncbi.nlm.nih.gov/pubmed/34502683
http://dx.doi.org/10.3390/s21175792
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