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Enantioselectivity Effects in Clinical Metabolomics and Lipidomics

Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids...

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Autores principales: Oliveira, Regina V., Simionato, Ana Valéria C., Cass, Quezia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433918/
https://www.ncbi.nlm.nih.gov/pubmed/34500665
http://dx.doi.org/10.3390/molecules26175231
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author Oliveira, Regina V.
Simionato, Ana Valéria C.
Cass, Quezia B.
author_facet Oliveira, Regina V.
Simionato, Ana Valéria C.
Cass, Quezia B.
author_sort Oliveira, Regina V.
collection PubMed
description Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples.
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spelling pubmed-84339182021-09-12 Enantioselectivity Effects in Clinical Metabolomics and Lipidomics Oliveira, Regina V. Simionato, Ana Valéria C. Cass, Quezia B. Molecules Review Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples. MDPI 2021-08-28 /pmc/articles/PMC8433918/ /pubmed/34500665 http://dx.doi.org/10.3390/molecules26175231 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliveira, Regina V.
Simionato, Ana Valéria C.
Cass, Quezia B.
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_full Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_fullStr Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_full_unstemmed Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_short Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_sort enantioselectivity effects in clinical metabolomics and lipidomics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433918/
https://www.ncbi.nlm.nih.gov/pubmed/34500665
http://dx.doi.org/10.3390/molecules26175231
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