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Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers

Chitosan belongs to the group of biopolymers with increasing range of potential applications therefore searching for new raw materials as well as new techniques of obtaining of this polysaccharide are currently a subject of interest of many scientists. Presented manuscript describes preparation of c...

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Autores principales: Głąb, Magdalena, Kudłacik-Kramarczyk, Sonia, Drabczyk, Anna, Guigou, Martin Duarte, Sobczak-Kupiec, Agnieszka, Mierzwiński, Dariusz, Gajda, Paweł, Walter, Janusz, Tyliszczak, Bożena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434013/
https://www.ncbi.nlm.nih.gov/pubmed/34501160
http://dx.doi.org/10.3390/ma14175070
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author Głąb, Magdalena
Kudłacik-Kramarczyk, Sonia
Drabczyk, Anna
Guigou, Martin Duarte
Sobczak-Kupiec, Agnieszka
Mierzwiński, Dariusz
Gajda, Paweł
Walter, Janusz
Tyliszczak, Bożena
author_facet Głąb, Magdalena
Kudłacik-Kramarczyk, Sonia
Drabczyk, Anna
Guigou, Martin Duarte
Sobczak-Kupiec, Agnieszka
Mierzwiński, Dariusz
Gajda, Paweł
Walter, Janusz
Tyliszczak, Bożena
author_sort Głąb, Magdalena
collection PubMed
description Chitosan belongs to the group of biopolymers with increasing range of potential applications therefore searching for new raw materials as well as new techniques of obtaining of this polysaccharide are currently a subject of interest of many scientists. Presented manuscript describes preparation of chitosan from crickets. Obtainment of final product required a number of processes aimed at removal of undesirable substances such as waxes, mineral salts, proteins or pigments from above-mentioned insects. Chemical structure of fractions obtained after each step was compared with the structure of commercial chitosan by means of techniques such as X-ray diffraction and FT-IR spectroscopy. Final product was subsequently used for preparation of polymer capsules that were modified with active substance characterized by antibacterial and anticancer activity—nisin. Next, sorption capacity of obtained materials was evaluated as well as a release profile of active substance in different environments. Based on the conducted research it can be concluded that crickets constitute an alternative for shellfish and other conventional sources of chitosan. Furthermore, obtained capsules on the basis of such prepared chitosan can be considered as drug delivery systems which efficiency of release of active substance is bigger in alkaline environments.
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spelling pubmed-84340132021-09-12 Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers Głąb, Magdalena Kudłacik-Kramarczyk, Sonia Drabczyk, Anna Guigou, Martin Duarte Sobczak-Kupiec, Agnieszka Mierzwiński, Dariusz Gajda, Paweł Walter, Janusz Tyliszczak, Bożena Materials (Basel) Article Chitosan belongs to the group of biopolymers with increasing range of potential applications therefore searching for new raw materials as well as new techniques of obtaining of this polysaccharide are currently a subject of interest of many scientists. Presented manuscript describes preparation of chitosan from crickets. Obtainment of final product required a number of processes aimed at removal of undesirable substances such as waxes, mineral salts, proteins or pigments from above-mentioned insects. Chemical structure of fractions obtained after each step was compared with the structure of commercial chitosan by means of techniques such as X-ray diffraction and FT-IR spectroscopy. Final product was subsequently used for preparation of polymer capsules that were modified with active substance characterized by antibacterial and anticancer activity—nisin. Next, sorption capacity of obtained materials was evaluated as well as a release profile of active substance in different environments. Based on the conducted research it can be concluded that crickets constitute an alternative for shellfish and other conventional sources of chitosan. Furthermore, obtained capsules on the basis of such prepared chitosan can be considered as drug delivery systems which efficiency of release of active substance is bigger in alkaline environments. MDPI 2021-09-04 /pmc/articles/PMC8434013/ /pubmed/34501160 http://dx.doi.org/10.3390/ma14175070 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Głąb, Magdalena
Kudłacik-Kramarczyk, Sonia
Drabczyk, Anna
Guigou, Martin Duarte
Sobczak-Kupiec, Agnieszka
Mierzwiński, Dariusz
Gajda, Paweł
Walter, Janusz
Tyliszczak, Bożena
Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title_full Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title_fullStr Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title_full_unstemmed Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title_short Multistep Chemical Processing of Crickets Leading to the Extraction of Chitosan Used for Synthesis of Polymer Drug Carriers
title_sort multistep chemical processing of crickets leading to the extraction of chitosan used for synthesis of polymer drug carriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434013/
https://www.ncbi.nlm.nih.gov/pubmed/34501160
http://dx.doi.org/10.3390/ma14175070
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