Cargando…

Chemistry of Peptide-Oligonucleotide Conjugates: A Review

Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as, antisense oligonucleotides and small interfering R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klabenkova, Kristina, Fokina, Alesya, Stetsenko, Dmitry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434111/ https://www.ncbi.nlm.nih.gov/pubmed/34500849 http://dx.doi.org/10.3390/molecules26175420

Ejemplares similares

Template-Assisted Assembly of Hybrid DNA/RNA Nanostructures Using Branched Oligodeoxy- and Oligoribonucleotides
por: Fokina, Alesya, et al.
Publicado: (2023)

Design and Properties of Ligand-Conjugated Guanine Oligonucleotides for Recovery of Mutated G-Quadruplexes
por: Takahashi, Shuntaro, et al.
Publicado: (2018)

Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry
por: Shabanpoor, Fazel, et al.
Publicado: (2013)

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties
por: Miroshnichenko, S. K., et al.
Publicado: (2019)

Synthesis of Protein-Oligonucleotide Conjugates
por: Watson, Emma E., et al.
Publicado: (2022)

Peptide Conjugation via CuAAC ‘Click’ Chemistry
por: Ahmad Fuaad, Abdullah A. H., et al.
Publicado: (2013)

Cell penetrating peptide conjugates of steric block oligonucleotides()
por: Lebleu, Bernard, et al.
Publicado: (2008)

Anticoagulant Oligonucleotide–Peptide Conjugates: Identification of Thrombin Aptamer Conjugates with Improved Characteristics
por: Tsvetkov, Vladimir B., et al.
Publicado: (2022)

Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates
por: Dugal-Tessier, Julien, et al.
Publicado: (2021)

Phosphate-modif ied CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells
por: Ostanin, A.A., et al.
Publicado: (2020)

Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules
por: Terada, Chisato, et al.
Publicado: (2022)

Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies
por: Fàbrega, Carme, et al.
Publicado: (2023)

The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
por: Agrawal, Sudhir
Publicado: (2021)

Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules
por: Hawner, Manuel, et al.
Publicado: (2020)

Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold
por: Zhao, Xing-Liang, et al.
Publicado: (2015)

Efficient Synthesis of 2’‐O‐Methoxyethyl Oligonucleotide‐Cationic Peptide Conjugates
por: Halloy, François, et al.
Publicado: (2021)

Diels-Alder cycloadditions in water for the straightforward preparation of peptide–oligonucleotide conjugates
por: Marchán, Vicente, et al.
Publicado: (2006)

Diels-Alder cycloadditions in water for the straightforward preparation of peptide–oligonucleotide conjugates
por: Marcha´n, Vicente, et al.
Publicado: (2006)

Coupling Strategies for the Synthesis of Peptide-Oligonucleotide Conjugates for Patterned Synthetic Biomineralization
por: Carter, Joshua D., et al.
Publicado: (2011)

Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P
por: Novopashina, Darya, et al.
Publicado: (2019)

Cationic oligonucleotide derivatives and conjugates: A favorable approach for enhanced DNA and RNA targeting oligonucleotides
por: Danielsen, Mathias B, et al.
Publicado: (2021)

The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides
por: Bege, Miklós, et al.
Publicado: (2022)

Chemistry, structure and function of approved oligonucleotide therapeutics
por: Egli, Martin, et al.
Publicado: (2023)

Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
por: Tran, Phuc, et al.
Publicado: (2022)

Lipid–oligonucleotide conjugates for bioapplications
por: Li, Xiaowei, et al.
Publicado: (2020)

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
por: Dastpeyman, Mohadeseh, et al.
Publicado: (2021)

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry
por: Paul, Sibasish, et al.
Publicado: (2023)

The role of chemistry in the success of oligonucleotides as therapeutics
por: Kumar, Pawan, et al.
Publicado: (2022)

Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies
por: Anwar, Saeed, et al.
Publicado: (2023)

New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides
por: Honcharenko, Dmytro, et al.
Publicado: (2020)

Antibody-drug conjugates: recent advances in conjugation and linker chemistries
por: Tsuchikama, Kyoji, et al.
Publicado: (2016)

Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides
por: Saleh, Amer F., et al.
Publicado: (2010)

2020 FDA TIDES (Peptides and Oligonucleotides) Harvest
por: Al Musaimi, Othman, et al.
Publicado: (2021)

2019 FDA TIDES (Peptides and Oligonucleotides) Harvest
por: Al Shaer, Danah, et al.
Publicado: (2020)

2021 FDA TIDES (Peptides and Oligonucleotides) Harvest
por: Al Shaer, Danah, et al.
Publicado: (2022)

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment
por: Gait, Michael J., et al.
Publicado: (2019)

Enhanced oligonucleotide–nanoparticle conjugate stability using thioctic acid modified oligonucleotides
por: Dougan, Jennifer A., et al.
Publicado: (2007)

Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers
por: Proskurina, Anastasia S., et al.
Publicado: (2023)

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides
por: Tone, Yuichiro, et al.
Publicado: (2021)

Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
por: Lou, Chenguang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u3dujh7kqaiicu40brc8m0iit3