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Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds

Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentiall...

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Detalles Bibliográficos
Autores principales: Vaz, Raquel, Valpradinhos, Beatriz, Frasco, Manuela F., Sales, Maria Goreti F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434157/
https://www.ncbi.nlm.nih.gov/pubmed/34502675
http://dx.doi.org/10.3390/s21175784
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author Vaz, Raquel
Valpradinhos, Beatriz
Frasco, Manuela F.
Sales, Maria Goreti F.
author_facet Vaz, Raquel
Valpradinhos, Beatriz
Frasco, Manuela F.
Sales, Maria Goreti F.
author_sort Vaz, Raquel
collection PubMed
description Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentially dangerous toxic compounds and to promote pharmacological innovation in drug discovery, as these compounds have unique chemical compositions that may be characterized by greater safety and efficacy. However, conventional methods for detecting these biomolecules have drawbacks, as they are time-consuming and expensive. As an alternative, optical biosensors offer a faster, simpler, and less expensive means of detecting various biomolecules of clinical interest. In this review, an overview of recent developments in optical biosensors for the detection and monitoring of aquatic biotoxins to prevent public health risks is first provided. In addition, the advantages and applicability of these biosensors in the field of drug discovery, including high-throughput screening, are discussed. The contribution of the investigated technological advances in the timely and sensitive detection of biotoxins while deciphering the pathways to discover bioactive compounds with great health-promoting prospects is envisaged to meet the increasing demands of healthcare systems.
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spelling pubmed-84341572021-09-12 Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds Vaz, Raquel Valpradinhos, Beatriz Frasco, Manuela F. Sales, Maria Goreti F. Sensors (Basel) Review Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentially dangerous toxic compounds and to promote pharmacological innovation in drug discovery, as these compounds have unique chemical compositions that may be characterized by greater safety and efficacy. However, conventional methods for detecting these biomolecules have drawbacks, as they are time-consuming and expensive. As an alternative, optical biosensors offer a faster, simpler, and less expensive means of detecting various biomolecules of clinical interest. In this review, an overview of recent developments in optical biosensors for the detection and monitoring of aquatic biotoxins to prevent public health risks is first provided. In addition, the advantages and applicability of these biosensors in the field of drug discovery, including high-throughput screening, are discussed. The contribution of the investigated technological advances in the timely and sensitive detection of biotoxins while deciphering the pathways to discover bioactive compounds with great health-promoting prospects is envisaged to meet the increasing demands of healthcare systems. MDPI 2021-08-27 /pmc/articles/PMC8434157/ /pubmed/34502675 http://dx.doi.org/10.3390/s21175784 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vaz, Raquel
Valpradinhos, Beatriz
Frasco, Manuela F.
Sales, Maria Goreti F.
Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title_full Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title_fullStr Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title_full_unstemmed Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title_short Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds
title_sort emerging optical materials in sensing and discovery of bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434157/
https://www.ncbi.nlm.nih.gov/pubmed/34502675
http://dx.doi.org/10.3390/s21175784
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