Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions

An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied usi...

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Autores principales: Hrizi, Asma, Cailler, Manon, Romdhani-Younes, Moufida, Carcenac, Yvan, Thibonnet, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434198/
https://www.ncbi.nlm.nih.gov/pubmed/34500719
http://dx.doi.org/10.3390/molecules26175287
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author Hrizi, Asma
Cailler, Manon
Romdhani-Younes, Moufida
Carcenac, Yvan
Thibonnet, Jérôme
author_facet Hrizi, Asma
Cailler, Manon
Romdhani-Younes, Moufida
Carcenac, Yvan
Thibonnet, Jérôme
author_sort Hrizi, Asma
collection PubMed
description An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles.
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spelling pubmed-84341982021-09-12 Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions Hrizi, Asma Cailler, Manon Romdhani-Younes, Moufida Carcenac, Yvan Thibonnet, Jérôme Molecules Article An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles. MDPI 2021-08-31 /pmc/articles/PMC8434198/ /pubmed/34500719 http://dx.doi.org/10.3390/molecules26175287 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hrizi, Asma
Cailler, Manon
Romdhani-Younes, Moufida
Carcenac, Yvan
Thibonnet, Jérôme
Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title_full Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title_fullStr Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title_full_unstemmed Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title_short Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
title_sort synthesis of new highly functionalized 1h-indole-2-carbonitriles via cross-coupling reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434198/
https://www.ncbi.nlm.nih.gov/pubmed/34500719
http://dx.doi.org/10.3390/molecules26175287
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