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Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434352/ https://www.ncbi.nlm.nih.gov/pubmed/34500746 http://dx.doi.org/10.3390/molecules26175312 |
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author | Gomes, Ana T. P. C. Neves, M. Graça P. M. S. Fernandes, Rosa Ribeiro, Carlos F. Cavaleiro, José A. S. Moura, Nuno M. M. |
author_facet | Gomes, Ana T. P. C. Neves, M. Graça P. M. S. Fernandes, Rosa Ribeiro, Carlos F. Cavaleiro, José A. S. Moura, Nuno M. M. |
author_sort | Gomes, Ana T. P. C. |
collection | PubMed |
description | In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells. |
format | Online Article Text |
id | pubmed-8434352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84343522021-09-12 Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells Gomes, Ana T. P. C. Neves, M. Graça P. M. S. Fernandes, Rosa Ribeiro, Carlos F. Cavaleiro, José A. S. Moura, Nuno M. M. Molecules Article In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells. MDPI 2021-09-01 /pmc/articles/PMC8434352/ /pubmed/34500746 http://dx.doi.org/10.3390/molecules26175312 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gomes, Ana T. P. C. Neves, M. Graça P. M. S. Fernandes, Rosa Ribeiro, Carlos F. Cavaleiro, José A. S. Moura, Nuno M. M. Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title_full | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title_fullStr | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title_full_unstemmed | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title_short | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells |
title_sort | unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434352/ https://www.ncbi.nlm.nih.gov/pubmed/34500746 http://dx.doi.org/10.3390/molecules26175312 |
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