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Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivati...

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Detalles Bibliográficos
Autores principales: Gomes, Ana T. P. C., Neves, M. Graça P. M. S., Fernandes, Rosa, Ribeiro, Carlos F., Cavaleiro, José A. S., Moura, Nuno M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434352/
https://www.ncbi.nlm.nih.gov/pubmed/34500746
http://dx.doi.org/10.3390/molecules26175312
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author Gomes, Ana T. P. C.
Neves, M. Graça P. M. S.
Fernandes, Rosa
Ribeiro, Carlos F.
Cavaleiro, José A. S.
Moura, Nuno M. M.
author_facet Gomes, Ana T. P. C.
Neves, M. Graça P. M. S.
Fernandes, Rosa
Ribeiro, Carlos F.
Cavaleiro, José A. S.
Moura, Nuno M. M.
author_sort Gomes, Ana T. P. C.
collection PubMed
description In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.
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spelling pubmed-84343522021-09-12 Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells Gomes, Ana T. P. C. Neves, M. Graça P. M. S. Fernandes, Rosa Ribeiro, Carlos F. Cavaleiro, José A. S. Moura, Nuno M. M. Molecules Article In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells. MDPI 2021-09-01 /pmc/articles/PMC8434352/ /pubmed/34500746 http://dx.doi.org/10.3390/molecules26175312 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gomes, Ana T. P. C.
Neves, M. Graça P. M. S.
Fernandes, Rosa
Ribeiro, Carlos F.
Cavaleiro, José A. S.
Moura, Nuno M. M.
Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title_full Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title_fullStr Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title_full_unstemmed Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title_short Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
title_sort unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434352/
https://www.ncbi.nlm.nih.gov/pubmed/34500746
http://dx.doi.org/10.3390/molecules26175312
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