Cargando…

Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior

This work aimed to develop and evaluate the influence of processing variables on the morphology and swelling of sulfonated poly(ether ether ketone) (SPEEK) spheres for possible applications as a biomaterial. We used the drip method to obtain spheres with the polymer starting solutions SPEEK-6 (w/v:...

Descripción completa

Detalles Bibliográficos
Autores principales: de Sá, Mayelli Dantas, de Lima Souza, José William, da Silva, Henrique Nunes, Torres, Rodolfo Henrique Nogueira, Leite, Michele Dayane Rodrigues, Barbosa, Rossemberg Cardoso, Leite, Itamara Farias, Pimentel, Cristiane Agra, Fook, Marcus Vinicius Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434384/
https://www.ncbi.nlm.nih.gov/pubmed/34502960
http://dx.doi.org/10.3390/polym13172920
_version_ 1783751585971568640
author de Sá, Mayelli Dantas
de Lima Souza, José William
da Silva, Henrique Nunes
Torres, Rodolfo Henrique Nogueira
Leite, Michele Dayane Rodrigues
Barbosa, Rossemberg Cardoso
Leite, Itamara Farias
Pimentel, Cristiane Agra
Fook, Marcus Vinicius Lia
author_facet de Sá, Mayelli Dantas
de Lima Souza, José William
da Silva, Henrique Nunes
Torres, Rodolfo Henrique Nogueira
Leite, Michele Dayane Rodrigues
Barbosa, Rossemberg Cardoso
Leite, Itamara Farias
Pimentel, Cristiane Agra
Fook, Marcus Vinicius Lia
author_sort de Sá, Mayelli Dantas
collection PubMed
description This work aimed to develop and evaluate the influence of processing variables on the morphology and swelling of sulfonated poly(ether ether ketone) (SPEEK) spheres for possible applications as a biomaterial. We used the drip method to obtain spheres with the polymer starting solutions SPEEK-6 (w/v: 6%) and SPEEK-10 (w/v: 10%), drip rates (20 and 30 mL/h), and drip heights (5 and 10 cm) in experimental planning. The samples were characterized by Fourier-transform infrared spectroscopy (FTIR), optical microscopy (OM), the absorption capacity of phosphate-buffered saline (PBS) by swelling (%), and statistical analysis of data through Design of Experiments (DOE). The obtained results evidenced that the processing variables influenced the morphology and swelling. Spheres with a bigger concentration of the polymer solution presented a greater degree of sulfonation (DS). We verified that the diameter of the spheres was directly related to the variable height and the sphericity was associated with the speed and viscosity of the solution. Bigger and more pores in a greater amount were observed in the spheres with a greater DS, influencing the behavior of the swelling in PBS. The better variable combinations with a high DS, regular sphericity, a smaller diameter, and greater swelling were the samples S(2)-10-20-5 e S(10)-10-20-5. The cytotoxicity indicated that the best samples obtained in the experimental planning (S(2)-10-20-5 and S(10)-10-20-5) were not toxic. In that regard, the evaluated spheres presented cell viability and swelling capacity, suggesting their possible applications as biomaterials.
format Online
Article
Text
id pubmed-8434384
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84343842021-09-12 Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior de Sá, Mayelli Dantas de Lima Souza, José William da Silva, Henrique Nunes Torres, Rodolfo Henrique Nogueira Leite, Michele Dayane Rodrigues Barbosa, Rossemberg Cardoso Leite, Itamara Farias Pimentel, Cristiane Agra Fook, Marcus Vinicius Lia Polymers (Basel) Article This work aimed to develop and evaluate the influence of processing variables on the morphology and swelling of sulfonated poly(ether ether ketone) (SPEEK) spheres for possible applications as a biomaterial. We used the drip method to obtain spheres with the polymer starting solutions SPEEK-6 (w/v: 6%) and SPEEK-10 (w/v: 10%), drip rates (20 and 30 mL/h), and drip heights (5 and 10 cm) in experimental planning. The samples were characterized by Fourier-transform infrared spectroscopy (FTIR), optical microscopy (OM), the absorption capacity of phosphate-buffered saline (PBS) by swelling (%), and statistical analysis of data through Design of Experiments (DOE). The obtained results evidenced that the processing variables influenced the morphology and swelling. Spheres with a bigger concentration of the polymer solution presented a greater degree of sulfonation (DS). We verified that the diameter of the spheres was directly related to the variable height and the sphericity was associated with the speed and viscosity of the solution. Bigger and more pores in a greater amount were observed in the spheres with a greater DS, influencing the behavior of the swelling in PBS. The better variable combinations with a high DS, regular sphericity, a smaller diameter, and greater swelling were the samples S(2)-10-20-5 e S(10)-10-20-5. The cytotoxicity indicated that the best samples obtained in the experimental planning (S(2)-10-20-5 and S(10)-10-20-5) were not toxic. In that regard, the evaluated spheres presented cell viability and swelling capacity, suggesting their possible applications as biomaterials. MDPI 2021-08-30 /pmc/articles/PMC8434384/ /pubmed/34502960 http://dx.doi.org/10.3390/polym13172920 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Sá, Mayelli Dantas
de Lima Souza, José William
da Silva, Henrique Nunes
Torres, Rodolfo Henrique Nogueira
Leite, Michele Dayane Rodrigues
Barbosa, Rossemberg Cardoso
Leite, Itamara Farias
Pimentel, Cristiane Agra
Fook, Marcus Vinicius Lia
Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title_full Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title_fullStr Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title_full_unstemmed Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title_short Biocompatible Sulphonated PEEK Spheres: Influence of Processing Conditions on Morphology and Swelling Behavior
title_sort biocompatible sulphonated peek spheres: influence of processing conditions on morphology and swelling behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434384/
https://www.ncbi.nlm.nih.gov/pubmed/34502960
http://dx.doi.org/10.3390/polym13172920
work_keys_str_mv AT desamayellidantas biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT delimasouzajosewilliam biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT dasilvahenriquenunes biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT torresrodolfohenriquenogueira biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT leitemicheledayanerodrigues biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT barbosarossembergcardoso biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT leiteitamarafarias biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT pimentelcristianeagra biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior
AT fookmarcusviniciuslia biocompatiblesulphonatedpeekspheresinfluenceofprocessingconditionsonmorphologyandswellingbehavior