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Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More...

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Autores principales: Corsaro, Carmelo, Neri, Giulia, Mezzasalma, Angela Maria, Fazio, Enza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434431/
https://www.ncbi.nlm.nih.gov/pubmed/34502937
http://dx.doi.org/10.3390/polym13172897
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author Corsaro, Carmelo
Neri, Giulia
Mezzasalma, Angela Maria
Fazio, Enza
author_facet Corsaro, Carmelo
Neri, Giulia
Mezzasalma, Angela Maria
Fazio, Enza
author_sort Corsaro, Carmelo
collection PubMed
description Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More attention has recently been paid to synthetic polyelectrolytes for their intrinsic properties which allow them to rearrange into compact structures, ideal to be used as drug carriers or probes influencing biochemical processes. The presence of Ag nanoparticles (NPs) in the Poly methyl acrylate (PMA) matrix leads to an enhancement of drug release efficiency, even using a low-power laser whose wavelength is far from the Ag Surface Plasmon Resonance (SPR) peak. Further, compared to the colloids, the nanofiber-based drug delivery system has shown shorter response time and more precise control over the release rate. The efficiency and timing of involved drug release mechanisms has been estimated by the Weibull distribution function, whose parameters indicate that the release mechanism of nanofibers obeys Fick’s first law while a non-Fickian character controlled by diffusion and relaxation of polymer chains occurs in the colloidal phase.
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spelling pubmed-84344312021-09-12 Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems Corsaro, Carmelo Neri, Giulia Mezzasalma, Angela Maria Fazio, Enza Polymers (Basel) Article Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More attention has recently been paid to synthetic polyelectrolytes for their intrinsic properties which allow them to rearrange into compact structures, ideal to be used as drug carriers or probes influencing biochemical processes. The presence of Ag nanoparticles (NPs) in the Poly methyl acrylate (PMA) matrix leads to an enhancement of drug release efficiency, even using a low-power laser whose wavelength is far from the Ag Surface Plasmon Resonance (SPR) peak. Further, compared to the colloids, the nanofiber-based drug delivery system has shown shorter response time and more precise control over the release rate. The efficiency and timing of involved drug release mechanisms has been estimated by the Weibull distribution function, whose parameters indicate that the release mechanism of nanofibers obeys Fick’s first law while a non-Fickian character controlled by diffusion and relaxation of polymer chains occurs in the colloidal phase. MDPI 2021-08-27 /pmc/articles/PMC8434431/ /pubmed/34502937 http://dx.doi.org/10.3390/polym13172897 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corsaro, Carmelo
Neri, Giulia
Mezzasalma, Angela Maria
Fazio, Enza
Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title_full Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title_fullStr Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title_full_unstemmed Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title_short Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems
title_sort weibull modeling of controlled drug release from ag-pma nanosystems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434431/
https://www.ncbi.nlm.nih.gov/pubmed/34502937
http://dx.doi.org/10.3390/polym13172897
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