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QSAR-Based Computational Approaches to Accelerate the Discovery of Sigma-2 Receptor (S2R) Ligands as Therapeutic Drugs

S2R overexpression is associated with various forms of cancer as well as both neuropsychiatric disorders (e.g., schizophrenia) and neurodegenerative diseases (Alzheimer’s disease: AD). In the present study, three ligand-based methods (QSAR modeling, pharmacophore mapping, and shape-based screening)...

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Detalles Bibliográficos
Autores principales:	Yu, Yangxi, Dong, Hiep, Peng, Youyi, Welsh, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434483/ https://www.ncbi.nlm.nih.gov/pubmed/34500703 http://dx.doi.org/10.3390/molecules26175270

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