Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents

The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were...

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Autores principales: Alsayari, Abdulrhman, Muhsinah, Abdullatif Bin, Asiri, Yahya I., Al-aizari, Faiz A., Kheder, Nabila A., Almarhoon, Zainab M., Ghabbour, Hazem A., Mabkhot, Yahia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434505/
https://www.ncbi.nlm.nih.gov/pubmed/34500816
http://dx.doi.org/10.3390/molecules26175383
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author Alsayari, Abdulrhman
Muhsinah, Abdullatif Bin
Asiri, Yahya I.
Al-aizari, Faiz A.
Kheder, Nabila A.
Almarhoon, Zainab M.
Ghabbour, Hazem A.
Mabkhot, Yahia N.
author_facet Alsayari, Abdulrhman
Muhsinah, Abdullatif Bin
Asiri, Yahya I.
Al-aizari, Faiz A.
Kheder, Nabila A.
Almarhoon, Zainab M.
Ghabbour, Hazem A.
Mabkhot, Yahia N.
author_sort Alsayari, Abdulrhman
collection PubMed
description The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, (1)H and (13)C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.
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spelling pubmed-84345052021-09-12 Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents Alsayari, Abdulrhman Muhsinah, Abdullatif Bin Asiri, Yahya I. Al-aizari, Faiz A. Kheder, Nabila A. Almarhoon, Zainab M. Ghabbour, Hazem A. Mabkhot, Yahia N. Molecules Article The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, (1)H and (13)C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules. MDPI 2021-09-04 /pmc/articles/PMC8434505/ /pubmed/34500816 http://dx.doi.org/10.3390/molecules26175383 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alsayari, Abdulrhman
Muhsinah, Abdullatif Bin
Asiri, Yahya I.
Al-aizari, Faiz A.
Kheder, Nabila A.
Almarhoon, Zainab M.
Ghabbour, Hazem A.
Mabkhot, Yahia N.
Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title_full Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title_fullStr Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title_full_unstemmed Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title_short Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
title_sort synthesis, characterization, and biological evaluation of some novel pyrazolo[5,1-b]thiazole derivatives as potential antimicrobial and anticancer agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434505/
https://www.ncbi.nlm.nih.gov/pubmed/34500816
http://dx.doi.org/10.3390/molecules26175383
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