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Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dre...

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Autores principales: Ndlovu, Sindi P., Ngece, Kwanele, Alven, Sibusiso, Aderibigbe, Blessing A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434607/
https://www.ncbi.nlm.nih.gov/pubmed/34502997
http://dx.doi.org/10.3390/polym13172959
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author Ndlovu, Sindi P.
Ngece, Kwanele
Alven, Sibusiso
Aderibigbe, Blessing A.
author_facet Ndlovu, Sindi P.
Ngece, Kwanele
Alven, Sibusiso
Aderibigbe, Blessing A.
author_sort Ndlovu, Sindi P.
collection PubMed
description Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.
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spelling pubmed-84346072021-09-12 Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings Ndlovu, Sindi P. Ngece, Kwanele Alven, Sibusiso Aderibigbe, Blessing A. Polymers (Basel) Review Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021. MDPI 2021-08-31 /pmc/articles/PMC8434607/ /pubmed/34502997 http://dx.doi.org/10.3390/polym13172959 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ndlovu, Sindi P.
Ngece, Kwanele
Alven, Sibusiso
Aderibigbe, Blessing A.
Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title_full Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title_fullStr Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title_full_unstemmed Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title_short Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings
title_sort gelatin-based hybrid scaffolds: promising wound dressings
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434607/
https://www.ncbi.nlm.nih.gov/pubmed/34502997
http://dx.doi.org/10.3390/polym13172959
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