Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma

BACKGROUND: Colorectal cancer (CRC) is a major cancer type whose mechanism of metastasis remains elusive. METHODS: In this study, we characterised the evolutionary pattern of metastatic CRC (mCRC) by analysing bulk and single-cell exome sequencing data of primary and metastatic tumours from 7 CRC pa...

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Detalles Bibliográficos
Autores principales: Tang, Jie, Tu, Kailing, Lu, Keying, Zhang, Jiaxun, Luo, Kai, Jin, Haoxuan, Wang, Lei, Yang, Lie, Xiao, Weiran, Zhang, Qilin, Liu, Xiaoling, Ge, Xin yi, Li, Guibo, Zhou, Zongguang, Xie, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434739/
https://www.ncbi.nlm.nih.gov/pubmed/34507604
http://dx.doi.org/10.1186/s13073-021-00962-3

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