Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe...

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Detalles Bibliográficos
Autores principales: Li, Yu, Xiao, Qing, Tang, Jie, Xiong, Lidan, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434831/
https://www.ncbi.nlm.nih.gov/pubmed/34522095
http://dx.doi.org/10.2147/IJN.S322356
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author Li, Yu
Xiao, Qing
Tang, Jie
Xiong, Lidan
Li, Li
author_facet Li, Yu
Xiao, Qing
Tang, Jie
Xiong, Lidan
Li, Li
author_sort Li, Yu
collection PubMed
description Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.
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spelling pubmed-84348312021-09-13 Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions Li, Yu Xiao, Qing Tang, Jie Xiong, Lidan Li, Li Int J Nanomedicine Review Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted. Dove 2021-09-07 /pmc/articles/PMC8434831/ /pubmed/34522095 http://dx.doi.org/10.2147/IJN.S322356 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Yu
Xiao, Qing
Tang, Jie
Xiong, Lidan
Li, Li
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_full Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_fullStr Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_full_unstemmed Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_short Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
title_sort extracellular vesicles: emerging therapeutics in cutaneous lesions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434831/
https://www.ncbi.nlm.nih.gov/pubmed/34522095
http://dx.doi.org/10.2147/IJN.S322356
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