Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents

Starting from the antimalarial drugs chloroquine and hydroxychloroquine, we conducted a structural optimization on the side chain of chloroquine by introducing amino substituted longer chains thus leading to a series of novel aminochloroquine derivatives. Anti-infectious effects against SARS-Cov2 sp...

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Detalles Bibliográficos
Autores principales: Song, Zilan, Liu, Yuting, Xie, Chenghu, Tong, Xiankun, Wang, Xue, Zhou, Yu, Gu, Wangting, Zuo, Jianping, He, Shijun, Zhang, Ao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434889/
https://www.ncbi.nlm.nih.gov/pubmed/34536929
http://dx.doi.org/10.1016/j.bioorg.2021.105346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434889/
https://www.ncbi.nlm.nih.gov/pubmed/34536929
http://dx.doi.org/10.1016/j.bioorg.2021.105346

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