Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti...

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Detalles Bibliográficos
Autores principales: Munuswamy, Revathy, De Brandt, Jana, Burtin, Chris, Derave, Wim, Aumann, Joseph, Spruit, Martijn A, Michiels, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434905/
https://www.ncbi.nlm.nih.gov/pubmed/34522118
http://dx.doi.org/10.2147/JIR.S320659
Descripción
Sumario:Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.

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