Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti...

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Autores principales: Munuswamy, Revathy, De Brandt, Jana, Burtin, Chris, Derave, Wim, Aumann, Joseph, Spruit, Martijn A, Michiels, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434905/
https://www.ncbi.nlm.nih.gov/pubmed/34522118
http://dx.doi.org/10.2147/JIR.S320659
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author Munuswamy, Revathy
De Brandt, Jana
Burtin, Chris
Derave, Wim
Aumann, Joseph
Spruit, Martijn A
Michiels, Luc
author_facet Munuswamy, Revathy
De Brandt, Jana
Burtin, Chris
Derave, Wim
Aumann, Joseph
Spruit, Martijn A
Michiels, Luc
author_sort Munuswamy, Revathy
collection PubMed
description Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.
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spelling pubmed-84349052021-09-13 Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons Munuswamy, Revathy De Brandt, Jana Burtin, Chris Derave, Wim Aumann, Joseph Spruit, Martijn A Michiels, Luc J Inflamm Res Research Letter Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation. Dove 2021-09-07 /pmc/articles/PMC8434905/ /pubmed/34522118 http://dx.doi.org/10.2147/JIR.S320659 Text en © 2021 Munuswamy et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Research Letter
Munuswamy, Revathy
De Brandt, Jana
Burtin, Chris
Derave, Wim
Aumann, Joseph
Spruit, Martijn A
Michiels, Luc
Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_full Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_fullStr Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_full_unstemmed Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_short Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
title_sort monomeric crp is elevated in patients with copd compared to non-copd control persons
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434905/
https://www.ncbi.nlm.nih.gov/pubmed/34522118
http://dx.doi.org/10.2147/JIR.S320659
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