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Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation
As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflamm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434908/ https://www.ncbi.nlm.nih.gov/pubmed/34522116 http://dx.doi.org/10.2147/JIR.S327291 |
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author | Pan, Yongli Jiao, Qingzheng Wei, Wei Zheng, Tianyang Yang, Xinyu Xin, Wenqiang |
author_facet | Pan, Yongli Jiao, Qingzheng Wei, Wei Zheng, Tianyang Yang, Xinyu Xin, Wenqiang |
author_sort | Pan, Yongli |
collection | PubMed |
description | As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient’s prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF‐κB and ERK. |
format | Online Article Text |
id | pubmed-8434908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-84349082021-09-13 Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation Pan, Yongli Jiao, Qingzheng Wei, Wei Zheng, Tianyang Yang, Xinyu Xin, Wenqiang J Inflamm Res Review As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient’s prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF‐κB and ERK. Dove 2021-09-07 /pmc/articles/PMC8434908/ /pubmed/34522116 http://dx.doi.org/10.2147/JIR.S327291 Text en © 2021 Pan et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Pan, Yongli Jiao, Qingzheng Wei, Wei Zheng, Tianyang Yang, Xinyu Xin, Wenqiang Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title | Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title_full | Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title_fullStr | Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title_full_unstemmed | Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title_short | Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation |
title_sort | emerging role of lncrnas in ischemic stroke—novel insights into the regulation of inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434908/ https://www.ncbi.nlm.nih.gov/pubmed/34522116 http://dx.doi.org/10.2147/JIR.S327291 |
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