Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity, and reproducibility of ctDNA assays is poorly understood. Here we report the findings of a multi-site, cross-platform evaluation of the analytical performance of five industry-lead...

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Detalles Bibliográficos
Autores principales: Deveson, Ira W., Gong, Binsheng, Lai, Kevin, LoCoco, Jennifer S., Richmond, Todd A., Schageman, Jeoffrey, Zhang, Zhihong, Novoradovskaya, Natalia, Willey, James C., Jones, Wendell, Kusko, Rebecca, Chen, Guangchun, Madala, Bindu Swapna, Blackburn, James, Stevanovski, Igor, Bhandari, Ambica, Close, Devin, Conroy, Jeffrey, Hubank, Michael, Marella, Narasimha, Mieczkowski, Piotr A., Qiu, Fujun, Sebra, Robert, Stetson, Daniel, Sun, Lihyun, Szankasi, Philippe, Tan, Haowen, Tang, Lin-ya, Arib, Hanane, Best, Hunter, Burgher, Blake, Bushel, Pierre R., Casey, Fergal, Cawley, Simon, Chang, Chia-Jung, Choi, Jonathan, Dinis, Jorge, Duncan, Daniel, Eterovic, Agda Karina, Feng, Liang, Ghosal, Abhisek, Giorda, Kristina, Glenn, Sean, Happe, Scott, Haseley, Nathan, Horvath, Kyle, Hung, Li-Yuan, Jarosz, Mirna, Kushwaha, Garima, Li, Dan, Li, Quan-Zhen, Li, Zhiguang, Liu, Liang-Chun, Liu, Zhichao, Ma, Charles, Mason, Christopher E., Megherbi, Dalila B., Morrison, Tom, Pabón-Peña, Carlos, Pirooznia, Mehdi, Proszek, Paula Z., Raymond, Amelia, Rindler, Paul, Ringler, Rebecca, Scherer, Andreas, Shaknovich, Rita, Shi, Tieliu, Smith, Melissa, Song, Ping, Strahl, Maya, Thodima, Venkat J., Tom, Nikola, Verma, Suman, Wang, Jiashi, Wu, Leihong, Xiao, Wenzhong, Xu, Chang, Yang, Mary, Zhang, Guangliang, Zhang, Sa, Zhang, Yilin, Shi, Leming, Tong, Weida, Johann, Donald J, Mercer, Timothy R., Xu, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434938/
https://www.ncbi.nlm.nih.gov/pubmed/33846644
http://dx.doi.org/10.1038/s41587-021-00857-z

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