Cargando…

Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide for almost 2 years. It starts from viral adherence to host cells through an interaction between spike glycoprotein 1 (S1) containing a receptor-binding domain (RB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Daixi, Wang, Cheng, Wang, Shaobo, Mehmood, Aamir, Gu, Jiang, Cheng, Xin, Chen, Peiqin, Qiu, JingFei, Zhao, Jinghong, Wang, Junping, Wei, Dongqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435140/ https://www.ncbi.nlm.nih.gov/pubmed/34510373 http://dx.doi.org/10.1007/s12539-021-00477-w

Ejemplares similares

HD5 and LL-37 Inhibit SARS-CoV and SARS-CoV-2 Binding to Human ACE2 by Molecular Simulation
por: Li, Daixi, et al.
Publicado: (2021)

Correction to: HD5 and LL‑37 Inhibit SARS‑CoV and SARS‑CoV‑2 Binding to Human ACE2 by Molecular Simulation
por: Li, Daixi, et al.
Publicado: (2021)

Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2
por: Wang, Cheng, et al.
Publicado: (2020)

Discovering potent inhibitors against the Mpro of the SARS-CoV-2. A medicinal chemistry approach
por: Mehmood, Aamir, et al.
Publicado: (2022)

Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening
por: Diao, Yanyan, et al.
Publicado: (2018)

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection
por: Guo, Yu, et al.
Publicado: (2023)

Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2
por: Shin, Young Sup, et al.
Publicado: (2021)

Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor
por: Wu, Qianqian, et al.
Publicado: (2022)

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening
por: Schardt, John S., et al.
Publicado: (2021)

Discovery of highly potent SARS-CoV-2 M(pro) inhibitors based on benzoisothiazolone scaffold
por: Chen, Weixiong, et al.
Publicado: (2022)

Discovery of 2-aminoquinolone acid derivatives as potent inhibitors of SARS-CoV-2
por: Shin, Young Sup, et al.
Publicado: (2023)

Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway
por: Wang, Shaobo, et al.
Publicado: (2022)

Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines
por: Zhao, Dong-Fang, et al.
Publicado: (2021)

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2
por: Chen, Hsiao-Fan, et al.
Publicado: (2023)

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
por: Zhang, Yuejuan, et al.
Publicado: (2022)

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
por: Zhang, Jing, et al.
Publicado: (2022)

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors
por: Cui, Jiahua, et al.
Publicado: (2021)

Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol
por: Ge, Haixia, et al.
Publicado: (2023)

Discovery of New Potent anti-MERS CoV Fusion Inhibitors
por: Kandeel, Mahmoud, et al.
Publicado: (2021)

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents
por: Zhang, Jidong, et al.
Publicado: (2023)

Discovery of Novel Dihydrolipoamide S-Succinyltransferase Inhibitors Based on Fragment Virtual Screening
por: Wei, Chengqian, et al.
Publicado: (2021)

Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors
por: Huff, Sarah, et al.
Publicado: (2021)

Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases
por: Kühl, Nikos, et al.
Publicado: (2022)

Discovery of potent STAT3 inhibitors using structure-based virtual screening, molecular dynamic simulation, and biological evaluation
por: Liu, Weifeng, et al.
Publicado: (2023)

Repositioning therapeutics for COVID-19: virtual screening of the potent synthetic and natural compounds as SARS-CoV-2 3CLpro inhibitors
por: Sattari, Ahmad, et al.
Publicado: (2021)

Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors
por: Zou, Yiquan, et al.
Publicado: (2013)

Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19
por: Dinda, Biswanath, et al.
Publicado: (2022)

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
por: Chen, Yidan, et al.
Publicado: (2020)

Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection
por: Yi, Yang, et al.
Publicado: (2021)

Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 M(pro) Protease through Virtual Screening
por: Rubio-Martínez, Jaime, et al.
Publicado: (2021)

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2
por: Lei, Hong, et al.
Publicado: (2020)

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
por: Lv, Zhe, et al.
Publicado: (2020)

Virtual screening for the discovery of bioactive natural products
por: Rollinger, Judith M., et al.
Publicado: (2008)

Discovery of potent and noncovalent KRAS(G12D) inhibitors: Structure-based virtual screening and biological evaluation
por: Wang, Yuting, et al.
Publicado: (2022)

Discovery of Taroxaz-104: The first potent antidote of SARS-CoV-2 VOC-202012/01 strain
por: Rabie, Amgad M.
Publicado: (2021)

Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors
por: Vijayan, Ramachandran, et al.
Publicado: (2021)

25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor
por: Zu, Shulong, et al.
Publicado: (2020)

Discovery and structural optimization of 3-O-β-chacotriosyl oleanane-type triterpenoids as potent entry inhibitors of SARS-CoV-2 virus infections
por: Li, Hui, et al.
Publicado: (2021)

Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease
por: Li, Lingyu, et al.
Publicado: (2022)

Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo
por: Pal, Rusha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_201k1n3t8uqa4mlm94g7gagem5